A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus

A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus

Background & Aims: High-dose irradiation is an essential tool to help control the growth of hepatic tumors, but it can cause radiation-induced liver disease (RILD). This life-threatening complication manifests itself months following radiation therapy and is characterized by fibrosis of the...

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Bibliographic Details
Main Authors: Nicolas Melin, Tural Yarahmadov, Daniel Sanchez-Taltavull, Fabienne E. Birrer, Tess M. Brodie, Benoît Petit, Andrea Felser, Jean-Marc Nuoffer, Matteo Montani, Marie-Catherine Vozenin, Evelyn Herrmann, Daniel Candinas, Daniel M. Aebersold, Deborah Stroka
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:JHEP Reports
Subjects:
radiation-induced liver disease (RILD)
sinusoidal obstruction syndrome
mouse model
mitochondrial dysfunction
fibrosis
p53
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555922000805

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