Systematic analysis of the varied designs of 819 therapeutic antibodies and Fc fusion proteins assigned international nonproprietary names
By combining and cross-checking data from the World Health Organization’s lists of international nonproprietary names with three other databases, we assembled a dataset of amino acid sequences of 819 antibody-related therapeutics. This enabled the systematic tabulation of 57 different molecular form...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | mAbs |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19420862.2022.2123299 |
| _version_ | 1798032875570855936 |
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| author | Ian Wilkinson Geoff Hale |
| author_facet | Ian Wilkinson Geoff Hale |
| author_sort | Ian Wilkinson |
| collection | DOAJ |
| description | By combining and cross-checking data from the World Health Organization’s lists of international nonproprietary names with three other databases, we assembled a dataset of amino acid sequences of 819 antibody-related therapeutics. This enabled the systematic tabulation of 57 different molecular formats and about 90 different constant-region variants (47 for silencing, 14 for enhancement, 8 for modifying binding to FcRn, 13 for heterodimerization, 4 for site-specific modification and 4 for stabilization), as well as the frequencies of different targets and immunoglobulin allotypes. The curated dataset provides a resource for researchers, giving insights into trends in antibody engineering and a guide to the most frequently tested designs. |
| first_indexed | 2024-04-11T20:21:00Z |
| format | Article |
| id | doaj.art-074a77fe06fc4eb4b299a08545d5fe15 |
| institution | Directory Open Access Journal |
| issn | 1942-0862 1942-0870 |
| language | English |
| last_indexed | 2024-04-11T20:21:00Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | mAbs |
| spelling | doaj.art-074a77fe06fc4eb4b299a08545d5fe152022-12-22T04:04:48ZengTaylor & Francis GroupmAbs1942-08621942-08702022-12-0114110.1080/19420862.2022.2123299Systematic analysis of the varied designs of 819 therapeutic antibodies and Fc fusion proteins assigned international nonproprietary namesIan Wilkinson0Geoff Hale1mAbsolve Limited, Oxford, UKmAbsolve Limited, Oxford, UKBy combining and cross-checking data from the World Health Organization’s lists of international nonproprietary names with three other databases, we assembled a dataset of amino acid sequences of 819 antibody-related therapeutics. This enabled the systematic tabulation of 57 different molecular formats and about 90 different constant-region variants (47 for silencing, 14 for enhancement, 8 for modifying binding to FcRn, 13 for heterodimerization, 4 for site-specific modification and 4 for stabilization), as well as the frequencies of different targets and immunoglobulin allotypes. The curated dataset provides a resource for researchers, giving insights into trends in antibody engineering and a guide to the most frequently tested designs.https://www.tandfonline.com/doi/10.1080/19420862.2022.2123299AllotypeFC regionFC receptortherapeutic antibodyimmunoglobulin fusion proteinimmunoglobulin sequence |
| spellingShingle | Ian Wilkinson Geoff Hale Systematic analysis of the varied designs of 819 therapeutic antibodies and Fc fusion proteins assigned international nonproprietary names mAbs Allotype FC region FC receptor therapeutic antibody immunoglobulin fusion protein immunoglobulin sequence |
| title | Systematic analysis of the varied designs of 819 therapeutic antibodies and Fc fusion proteins assigned international nonproprietary names |
| title_full | Systematic analysis of the varied designs of 819 therapeutic antibodies and Fc fusion proteins assigned international nonproprietary names |
| title_fullStr | Systematic analysis of the varied designs of 819 therapeutic antibodies and Fc fusion proteins assigned international nonproprietary names |
| title_full_unstemmed | Systematic analysis of the varied designs of 819 therapeutic antibodies and Fc fusion proteins assigned international nonproprietary names |
| title_short | Systematic analysis of the varied designs of 819 therapeutic antibodies and Fc fusion proteins assigned international nonproprietary names |
| title_sort | systematic analysis of the varied designs of 819 therapeutic antibodies and fc fusion proteins assigned international nonproprietary names |
| topic | Allotype FC region FC receptor therapeutic antibody immunoglobulin fusion protein immunoglobulin sequence |
| url | https://www.tandfonline.com/doi/10.1080/19420862.2022.2123299 |
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