Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative
Abstract Background Obsessive-compulsive disorder (OCD) has a lifetime prevalence of 2–3% and is a leading cause of global disability. Brain circuit abnormalities in individuals with OCD have been identified, but important knowledge gaps remain. The goal of the new global initiative described in thi...
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| Language: | English |
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BMC
2020-02-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-020-2439-2 |
| _version_ | 1818392927109382144 |
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| author | Helen Blair Simpson Odile A. van den Heuvel Euripedes C. Miguel Y. C. Janardhan Reddy Dan J. Stein Roberto Lewis-Fernández Roseli Gedanke Shavitt Christine Lochner Petra J. W. Pouwels Janardhanan C. Narayanawamy Ganesan Venkatasubramanian Dianne M. Hezel Chris Vriend Marcelo C. Batistuzzo Marcelo Q. Hoexter Niels T. de Joode Daniel Lucas Costa Maria Alice de Mathis Karthik Sheshachala Madhuri Narayan Anton J. L. M. van Balkom Neeltje M. Batelaan Shivakumar Venkataram Anish Cherian Clara Marincowitz Nienke Pannekoek Yael R. Stovezky Karen Mare Feng Liu Maria Concepcion Garcia Otaduy Bruno Pastorello Rashmi Rao Martha Katechis Page Van Meter Melanie Wall |
| author_facet | Helen Blair Simpson Odile A. van den Heuvel Euripedes C. Miguel Y. C. Janardhan Reddy Dan J. Stein Roberto Lewis-Fernández Roseli Gedanke Shavitt Christine Lochner Petra J. W. Pouwels Janardhanan C. Narayanawamy Ganesan Venkatasubramanian Dianne M. Hezel Chris Vriend Marcelo C. Batistuzzo Marcelo Q. Hoexter Niels T. de Joode Daniel Lucas Costa Maria Alice de Mathis Karthik Sheshachala Madhuri Narayan Anton J. L. M. van Balkom Neeltje M. Batelaan Shivakumar Venkataram Anish Cherian Clara Marincowitz Nienke Pannekoek Yael R. Stovezky Karen Mare Feng Liu Maria Concepcion Garcia Otaduy Bruno Pastorello Rashmi Rao Martha Katechis Page Van Meter Melanie Wall |
| author_sort | Helen Blair Simpson |
| collection | DOAJ |
| description | Abstract Background Obsessive-compulsive disorder (OCD) has a lifetime prevalence of 2–3% and is a leading cause of global disability. Brain circuit abnormalities in individuals with OCD have been identified, but important knowledge gaps remain. The goal of the new global initiative described in this paper is to identify robust and reproducible brain signatures of measurable behaviors and clinical symptoms that are common in individuals with OCD. A global approach was chosen to accelerate discovery, to increase rigor and transparency, and to ensure generalizability of results. Methods We will study 250 medication-free adults with OCD, 100 unaffected adult siblings of individuals with OCD, and 250 healthy control subjects at five expert research sites across five countries (Brazil, India, Netherlands, South Africa, and the U.S.). All participants will receive clinical evaluation, neurocognitive assessment, and magnetic resonance imaging (MRI). The imaging will examine multiple brain circuits hypothesized to underlie OCD behaviors, focusing on morphometry (T1-weighted MRI), structural connectivity (Diffusion Tensor Imaging), and functional connectivity (resting-state fMRI). In addition to analyzing each imaging modality separately, we will also use multi-modal fusion with machine learning statistical methods in an attempt to derive imaging signatures that distinguish individuals with OCD from unaffected siblings and healthy controls (Aim #1). Then we will examine how these imaging signatures link to behavioral performance on neurocognitive tasks that probe these same circuits as well as to clinical profiles (Aim #2). Finally, we will explore how specific environmental features (childhood trauma, socioeconomic status, and religiosity) moderate these brain-behavior associations. Discussion Using harmonized methods for data collection and analysis, we will conduct the largest neurocognitive and multimodal-imaging study in medication-free subjects with OCD to date. By recruiting a large, ethno-culturally diverse sample, we will test whether there are robust biosignatures of core OCD features that transcend countries and cultures. If so, future studies can use these brain signatures to reveal trans-diagnostic disease dimensions, chart when these signatures arise during development, and identify treatments that target these circuit abnormalities directly. The long-term goal of this research is to change not only how we conceptualize OCD but also how we diagnose and treat it. |
| first_indexed | 2024-12-14T05:37:11Z |
| format | Article |
| id | doaj.art-074aecc4ef244087b0ed5e610e37971a |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-14T05:37:11Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-074aecc4ef244087b0ed5e610e37971a2022-12-21T23:15:08ZengBMCBMC Psychiatry1471-244X2020-02-0120111410.1186/s12888-020-2439-2Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiativeHelen Blair Simpson0Odile A. van den Heuvel1Euripedes C. Miguel2Y. C. Janardhan Reddy3Dan J. Stein4Roberto Lewis-Fernández5Roseli Gedanke Shavitt6Christine Lochner7Petra J. W. Pouwels8Janardhanan C. Narayanawamy9Ganesan Venkatasubramanian10Dianne M. Hezel11Chris Vriend12Marcelo C. Batistuzzo13Marcelo Q. Hoexter14Niels T. de Joode15Daniel Lucas Costa16Maria Alice de Mathis17Karthik Sheshachala18Madhuri Narayan19Anton J. L. M. van Balkom20Neeltje M. Batelaan21Shivakumar Venkataram22Anish Cherian23Clara Marincowitz24Nienke Pannekoek25Yael R. Stovezky26Karen Mare27Feng Liu28Maria Concepcion Garcia Otaduy29Bruno Pastorello30Rashmi Rao31Martha Katechis32Page Van Meter33Melanie Wall34Columbia University Irving Medical Center, Columbia UniversityDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit AmsterdamObsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical SchoolNational Institute of Mental Health & Neurosciences (NIMHANS)SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape TownColumbia University Irving Medical Center, Columbia UniversityObsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical SchoolSAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch UniversityDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit AmsterdamNational Institute of Mental Health & Neurosciences (NIMHANS)National Institute of Mental Health & Neurosciences (NIMHANS)Columbia University Irving Medical Center, Columbia UniversityDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit AmsterdamObsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical SchoolObsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical SchoolDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit AmsterdamObsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical SchoolObsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical SchoolNational Institute of Mental Health & Neurosciences (NIMHANS)National Institute of Mental Health & Neurosciences (NIMHANS)Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research InstituteAmsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research InstituteNational Institute of Mental Health & Neurosciences (NIMHANS)National Institute of Mental Health & Neurosciences (NIMHANS)SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch UniversitySAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch UniversityColumbia University Irving Medical Center, Columbia UniversitySAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape TownColumbia University Irving Medical Center, Columbia UniversityObsessive-Compulsive Spectrum Disorders Program, Institute & Department of Psychiatry, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical SchoolInstitute of Radiology, Hospital das Clinicas-HCFMUSP, University of Sao Paulo Medical SchoolNational Institute of Mental Health & Neurosciences (NIMHANS)Columbia University Irving Medical Center, Columbia UniversityColumbia University Irving Medical Center, Columbia UniversityColumbia University Irving Medical Center, Columbia UniversityAbstract Background Obsessive-compulsive disorder (OCD) has a lifetime prevalence of 2–3% and is a leading cause of global disability. Brain circuit abnormalities in individuals with OCD have been identified, but important knowledge gaps remain. The goal of the new global initiative described in this paper is to identify robust and reproducible brain signatures of measurable behaviors and clinical symptoms that are common in individuals with OCD. A global approach was chosen to accelerate discovery, to increase rigor and transparency, and to ensure generalizability of results. Methods We will study 250 medication-free adults with OCD, 100 unaffected adult siblings of individuals with OCD, and 250 healthy control subjects at five expert research sites across five countries (Brazil, India, Netherlands, South Africa, and the U.S.). All participants will receive clinical evaluation, neurocognitive assessment, and magnetic resonance imaging (MRI). The imaging will examine multiple brain circuits hypothesized to underlie OCD behaviors, focusing on morphometry (T1-weighted MRI), structural connectivity (Diffusion Tensor Imaging), and functional connectivity (resting-state fMRI). In addition to analyzing each imaging modality separately, we will also use multi-modal fusion with machine learning statistical methods in an attempt to derive imaging signatures that distinguish individuals with OCD from unaffected siblings and healthy controls (Aim #1). Then we will examine how these imaging signatures link to behavioral performance on neurocognitive tasks that probe these same circuits as well as to clinical profiles (Aim #2). Finally, we will explore how specific environmental features (childhood trauma, socioeconomic status, and religiosity) moderate these brain-behavior associations. Discussion Using harmonized methods for data collection and analysis, we will conduct the largest neurocognitive and multimodal-imaging study in medication-free subjects with OCD to date. By recruiting a large, ethno-culturally diverse sample, we will test whether there are robust biosignatures of core OCD features that transcend countries and cultures. If so, future studies can use these brain signatures to reveal trans-diagnostic disease dimensions, chart when these signatures arise during development, and identify treatments that target these circuit abnormalities directly. The long-term goal of this research is to change not only how we conceptualize OCD but also how we diagnose and treat it.https://doi.org/10.1186/s12888-020-2439-2Obsessive-compulsive disorderNeuroimagingfMRIUnaffected siblingsBrain signaturesNeurocognitive |
| spellingShingle | Helen Blair Simpson Odile A. van den Heuvel Euripedes C. Miguel Y. C. Janardhan Reddy Dan J. Stein Roberto Lewis-Fernández Roseli Gedanke Shavitt Christine Lochner Petra J. W. Pouwels Janardhanan C. Narayanawamy Ganesan Venkatasubramanian Dianne M. Hezel Chris Vriend Marcelo C. Batistuzzo Marcelo Q. Hoexter Niels T. de Joode Daniel Lucas Costa Maria Alice de Mathis Karthik Sheshachala Madhuri Narayan Anton J. L. M. van Balkom Neeltje M. Batelaan Shivakumar Venkataram Anish Cherian Clara Marincowitz Nienke Pannekoek Yael R. Stovezky Karen Mare Feng Liu Maria Concepcion Garcia Otaduy Bruno Pastorello Rashmi Rao Martha Katechis Page Van Meter Melanie Wall Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative BMC Psychiatry Obsessive-compulsive disorder Neuroimaging fMRI Unaffected siblings Brain signatures Neurocognitive |
| title | Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative |
| title_full | Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative |
| title_fullStr | Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative |
| title_full_unstemmed | Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative |
| title_short | Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative |
| title_sort | toward identifying reproducible brain signatures of obsessive compulsive profiles rationale and methods for a new global initiative |
| topic | Obsessive-compulsive disorder Neuroimaging fMRI Unaffected siblings Brain signatures Neurocognitive |
| url | https://doi.org/10.1186/s12888-020-2439-2 |
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