Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative

Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative

Abstract Background Obsessive-compulsive disorder (OCD) has a lifetime prevalence of 2–3% and is a leading cause of global disability. Brain circuit abnormalities in individuals with OCD have been identified, but important knowledge gaps remain. The goal of the new global initiative described in thi...

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Main Authors: Helen Blair Simpson, Odile A. van den Heuvel, Euripedes C. Miguel, Y. C. Janardhan Reddy, Dan J. Stein, Roberto Lewis-Fernández, Roseli Gedanke Shavitt, Christine Lochner, Petra J. W. Pouwels, Janardhanan C. Narayanawamy, Ganesan Venkatasubramanian, Dianne M. Hezel, Chris Vriend, Marcelo C. Batistuzzo, Marcelo Q. Hoexter, Niels T. de Joode, Daniel Lucas Costa, Maria Alice de Mathis, Karthik Sheshachala, Madhuri Narayan, Anton J. L. M. van Balkom, Neeltje M. Batelaan, Shivakumar Venkataram, Anish Cherian, Clara Marincowitz, Nienke Pannekoek, Yael R. Stovezky, Karen Mare, Feng Liu, Maria Concepcion Garcia Otaduy, Bruno Pastorello, Rashmi Rao, Martha Katechis, Page Van Meter, Melanie Wall
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Psychiatry
Subjects:
Obsessive-compulsive disorder
Neuroimaging
fMRI
Unaffected siblings
Brain signatures
Neurocognitive
Online Access:https://doi.org/10.1186/s12888-020-2439-2

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