Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy
Abstract Background The extent of co-sensitization within and between food protein families in an adult population is largely unknown. This study aimed to identify the most frequently recognized components in the PR-10 and storage protein family, as well as patterns in (co-)sensitization, in a birch...
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| Format: | Article |
| Language: | English |
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Wiley
2017-11-01
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| Series: | Clinical and Translational Allergy |
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| Online Access: | http://link.springer.com/article/10.1186/s13601-017-0177-4 |
| _version_ | 1818880829267378176 |
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| author | Mark A. Blankestijn André C. Knulst Edward F. Knol Thuy-My Le Heike Rockmann Henny G. Otten Rob J. B. Klemans |
| author_facet | Mark A. Blankestijn André C. Knulst Edward F. Knol Thuy-My Le Heike Rockmann Henny G. Otten Rob J. B. Klemans |
| author_sort | Mark A. Blankestijn |
| collection | DOAJ |
| description | Abstract Background The extent of co-sensitization within and between food protein families in an adult population is largely unknown. This study aimed to identify the most frequently recognized components in the PR-10 and storage protein family, as well as patterns in (co-)sensitization, in a birch-endemic area. Methods Results of ImmunoCAP ISAC, performed during routine care in Dutch adult outpatients suspected of food allergy, were collected. Results A total of 305 patients were selected, aged 16–79 years (median 32 years). Sensitization to one or more PR-10 proteins was most frequent (74% of all subjects), followed by 35% to storage protein and 15% to nsLTPs. Within the PR-10 family, subjects were most often sensitized to Bet v 1 (73% of 305), Cor a 1.04 (72%) and Mal d 1 (68%). Sensitization to PR-10s from soy, celery and kiwi occurred distinctively less often (< 55% of Bet v 1 sensitized subjects) compared to other food PR-10s (all > 70%). Subjects sensitized to these ‘less common PR-10 proteins’ were sensitized to more food and inhalant components on the ISAC, compared to subjects sensitized to ‘common PR-10 proteins’ (median 22 vs 13 out of 112, p < 0.0001). Seven subjects demonstrated sensitization to food PR-10 proteins, without concomitant sensitization to pollen PR-10s. Within the storage proteins, sensitization to multiple peanut allergens was most common (on average 3 out of 4). Conclusions Sensitization to PR-10 food proteins could occur without concomitant sensitization to common PR-10 from pollen in a subset of subjects. Less commonly recognized PR-10 proteins appear to be an indication of polysensitization. |
| first_indexed | 2024-12-19T14:52:11Z |
| format | Article |
| id | doaj.art-074b38feaf9243228f089713f41c6cbf |
| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-12-19T14:52:11Z |
| publishDate | 2017-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-074b38feaf9243228f089713f41c6cbf2022-12-21T20:16:48ZengWileyClinical and Translational Allergy2045-70222017-11-01711810.1186/s13601-017-0177-4Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergyMark A. Blankestijn0André C. Knulst1Edward F. Knol2Thuy-My Le3Heike Rockmann4Henny G. Otten5Rob J. B. Klemans6Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht UniversityDepartment of Dermatology and Allergology, University Medical Center Utrecht, Utrecht UniversityDepartment of Dermatology and Allergology, University Medical Center Utrecht, Utrecht UniversityDepartment of Dermatology and Allergology, University Medical Center Utrecht, Utrecht UniversityDepartment of Dermatology and Allergology, University Medical Center Utrecht, Utrecht UniversityLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht UniversityDepartment of Dermatology and Allergology, University Medical Center Utrecht, Utrecht UniversityAbstract Background The extent of co-sensitization within and between food protein families in an adult population is largely unknown. This study aimed to identify the most frequently recognized components in the PR-10 and storage protein family, as well as patterns in (co-)sensitization, in a birch-endemic area. Methods Results of ImmunoCAP ISAC, performed during routine care in Dutch adult outpatients suspected of food allergy, were collected. Results A total of 305 patients were selected, aged 16–79 years (median 32 years). Sensitization to one or more PR-10 proteins was most frequent (74% of all subjects), followed by 35% to storage protein and 15% to nsLTPs. Within the PR-10 family, subjects were most often sensitized to Bet v 1 (73% of 305), Cor a 1.04 (72%) and Mal d 1 (68%). Sensitization to PR-10s from soy, celery and kiwi occurred distinctively less often (< 55% of Bet v 1 sensitized subjects) compared to other food PR-10s (all > 70%). Subjects sensitized to these ‘less common PR-10 proteins’ were sensitized to more food and inhalant components on the ISAC, compared to subjects sensitized to ‘common PR-10 proteins’ (median 22 vs 13 out of 112, p < 0.0001). Seven subjects demonstrated sensitization to food PR-10 proteins, without concomitant sensitization to pollen PR-10s. Within the storage proteins, sensitization to multiple peanut allergens was most common (on average 3 out of 4). Conclusions Sensitization to PR-10 food proteins could occur without concomitant sensitization to common PR-10 from pollen in a subset of subjects. Less commonly recognized PR-10 proteins appear to be an indication of polysensitization.http://link.springer.com/article/10.1186/s13601-017-0177-4ImmunoCAP ISACFood allergyPR-10Specific IgEStorage proteins |
| spellingShingle | Mark A. Blankestijn André C. Knulst Edward F. Knol Thuy-My Le Heike Rockmann Henny G. Otten Rob J. B. Klemans Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy Clinical and Translational Allergy ImmunoCAP ISAC Food allergy PR-10 Specific IgE Storage proteins |
| title | Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy |
| title_full | Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy |
| title_fullStr | Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy |
| title_full_unstemmed | Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy |
| title_short | Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy |
| title_sort | sensitization to pr 10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy |
| topic | ImmunoCAP ISAC Food allergy PR-10 Specific IgE Storage proteins |
| url | http://link.springer.com/article/10.1186/s13601-017-0177-4 |
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