Non breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control study
Abstract Background Sleep fragmentation was shown to be positively associated with cognitive impairment in patients with cerebral small vessel disease (CSVD); however, the underlying mechanisms are not well characterized. In this study, we sought to clarify this issue by investigating the relationsh...
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | BMC Neurology |
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| Online Access: | http://link.springer.com/article/10.1186/s12883-020-01647-x |
| _version_ | 1819111132350119936 |
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| author | Jihui Wang Xiaodong Chen Jinchi Liao Li Zhou Hongying Han Jiong Tao Zhengqi Lu |
| author_facet | Jihui Wang Xiaodong Chen Jinchi Liao Li Zhou Hongying Han Jiong Tao Zhengqi Lu |
| author_sort | Jihui Wang |
| collection | DOAJ |
| description | Abstract Background Sleep fragmentation was shown to be positively associated with cognitive impairment in patients with cerebral small vessel disease (CSVD); however, the underlying mechanisms are not well characterized. In this study, we sought to clarify this issue by investigating the relationship between non breathing-related sleep fragmentation and brain imaging markers in patients with CSVD. Methods Eighty-four CSVD patients and 24 age- and sex-matched healthy controls were prospectively recruited. All subjects underwent 3.0 T superconducting magnetic resonance imaging and overnight polysomnography. Polysomnography parameters including sleep onset latency (SOL), total sleep time (TST); sleep efficiency (SE), wake after sleep onset (WASO), percentage of each sleep stage (N1, N2, N3 and rapid eye movement [REM]), arousal index (ArI), periodic limb movement in sleep index (PLSMI), and periodic limb movement related arousal index (PLMAI) were compared between CSVD patients and healthy controls. The relationship between arousal index and CSVD markers was explored in the CSVD group. Results On polysomnography, CSVD patients showed significantly higher ArI, WASO, PLSMI, and PLMAI, and lower sleep efficiency and N− 3 ratio compared to healthy controls (p < 0.05). On ordinal logistic regression, higher ArI showed a positive association with the severity of periventricular white matter hyperintensity (odds ratio [OR] 1.121, 95% confidence interval [CI] 0.138–2.185) and perivascular space (OR 2.108, 95% CI 1.032–4.017) in CSVD patients, after adjusting for potential confounding variables. Conclusions These preliminary results indicate that non breathing-related sleep fragmentation is common and related to the pathological markers of CSVD patients. Future prospective research is required to determine the causal relationship between sleep parameters and CSVD pathology. |
| first_indexed | 2024-12-22T03:52:45Z |
| format | Article |
| id | doaj.art-074ba07ddadd43d1b3ea70400323efdb |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-22T03:52:45Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-074ba07ddadd43d1b3ea70400323efdb2022-12-21T18:39:57ZengBMCBMC Neurology1471-23772020-03-012011810.1186/s12883-020-01647-xNon breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control studyJihui Wang0Xiaodong Chen1Jinchi Liao2Li Zhou3Hongying Han4Jiong Tao5Zhengqi Lu6Department of Psychiatry, the Third Affiliated Hospital, Sun Yat-sen UniversityDepartment of Neurology, the Third Affiliated Hospital, Sun Yat-sen UniversityDepartment of Neurology, the Third Affiliated Hospital, Sun Yat-sen UniversityDepartment of Rehabilitative Medicine, the First Affiliated Hospital of Clinical Medicine of Guangdong Pharmaceutical UniversityDepartment of Psychiatry, the Third Affiliated Hospital, Sun Yat-sen UniversityDepartment of Psychiatry, the Third Affiliated Hospital, Sun Yat-sen UniversityDepartment of Neurology, the Third Affiliated Hospital, Sun Yat-sen UniversityAbstract Background Sleep fragmentation was shown to be positively associated with cognitive impairment in patients with cerebral small vessel disease (CSVD); however, the underlying mechanisms are not well characterized. In this study, we sought to clarify this issue by investigating the relationship between non breathing-related sleep fragmentation and brain imaging markers in patients with CSVD. Methods Eighty-four CSVD patients and 24 age- and sex-matched healthy controls were prospectively recruited. All subjects underwent 3.0 T superconducting magnetic resonance imaging and overnight polysomnography. Polysomnography parameters including sleep onset latency (SOL), total sleep time (TST); sleep efficiency (SE), wake after sleep onset (WASO), percentage of each sleep stage (N1, N2, N3 and rapid eye movement [REM]), arousal index (ArI), periodic limb movement in sleep index (PLSMI), and periodic limb movement related arousal index (PLMAI) were compared between CSVD patients and healthy controls. The relationship between arousal index and CSVD markers was explored in the CSVD group. Results On polysomnography, CSVD patients showed significantly higher ArI, WASO, PLSMI, and PLMAI, and lower sleep efficiency and N− 3 ratio compared to healthy controls (p < 0.05). On ordinal logistic regression, higher ArI showed a positive association with the severity of periventricular white matter hyperintensity (odds ratio [OR] 1.121, 95% confidence interval [CI] 0.138–2.185) and perivascular space (OR 2.108, 95% CI 1.032–4.017) in CSVD patients, after adjusting for potential confounding variables. Conclusions These preliminary results indicate that non breathing-related sleep fragmentation is common and related to the pathological markers of CSVD patients. Future prospective research is required to determine the causal relationship between sleep parameters and CSVD pathology.http://link.springer.com/article/10.1186/s12883-020-01647-xCerebral vascular diseaseSleepPolysomnographySleep fragmentationMarkers |
| spellingShingle | Jihui Wang Xiaodong Chen Jinchi Liao Li Zhou Hongying Han Jiong Tao Zhengqi Lu Non breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control study BMC Neurology Cerebral vascular disease Sleep Polysomnography Sleep fragmentation Markers |
| title | Non breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control study |
| title_full | Non breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control study |
| title_fullStr | Non breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control study |
| title_full_unstemmed | Non breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control study |
| title_short | Non breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control study |
| title_sort | non breathing related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease csvd a cross sectional case control study |
| topic | Cerebral vascular disease Sleep Polysomnography Sleep fragmentation Markers |
| url | http://link.springer.com/article/10.1186/s12883-020-01647-x |
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