infective endocarditis: A case report
Granulicatella elegans is a rare cause of infective endocarditis, accounting for 1–2% of all cases. It is well recognized that this pathogen can present in association with negative blood cultures. There are higher rates of both relapse and mortality compared with endocarditis caused by other bacter...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-11-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221135173 |
| _version_ | 1828200638270406656 |
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| author | Jana Deptová Laura Gombošová Marek Felšöci Eva Schréterová |
| author_facet | Jana Deptová Laura Gombošová Marek Felšöci Eva Schréterová |
| author_sort | Jana Deptová |
| collection | DOAJ |
| description | Granulicatella elegans is a rare cause of infective endocarditis, accounting for 1–2% of all cases. It is well recognized that this pathogen can present in association with negative blood cultures. There are higher rates of both relapse and mortality compared with endocarditis caused by other bacteria. Microbiological diagnosis can be especially challenging because many conventional blood culture media lack pyridoxal, which can be found in automated blood culture broths like BACTEC™ or BACT/ALERT® and thus they may require ‘helper’ bacteria to be culture the organism. This current case report describes a 66-year-old male patient with a 10-year history of post-inflammatory combined aortic valve disease (moderate aortic stenosis and mild aortic regurgitation). He presented with a 3-month history of recurrent fever and general deterioration. Despite targeted, prolonged, combined antibiotic treatment with intravenous penicillin and gentamicin, surgery was eventually required. An aortic prosthetic valve implantation was performed with good results. In case of subacute endocarditis, especially when a causative organism proves difficult to detect, G. elegans should be considered. Identification is greatly enhanced by using polymerase chain reaction methods and this test should be considered in all cases of culture negative endocarditis. |
| first_indexed | 2024-04-12T11:17:27Z |
| format | Article |
| id | doaj.art-074be1cb0b44409c865425bd78bfc3c4 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-04-12T11:17:27Z |
| publishDate | 2022-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-074be1cb0b44409c865425bd78bfc3c42022-12-22T03:35:27ZengSAGE PublishingJournal of International Medical Research1473-23002022-11-015010.1177/03000605221135173 infective endocarditis: A case reportJana DeptováLaura GombošováMarek FelšöciEva SchréterováGranulicatella elegans is a rare cause of infective endocarditis, accounting for 1–2% of all cases. It is well recognized that this pathogen can present in association with negative blood cultures. There are higher rates of both relapse and mortality compared with endocarditis caused by other bacteria. Microbiological diagnosis can be especially challenging because many conventional blood culture media lack pyridoxal, which can be found in automated blood culture broths like BACTEC™ or BACT/ALERT® and thus they may require ‘helper’ bacteria to be culture the organism. This current case report describes a 66-year-old male patient with a 10-year history of post-inflammatory combined aortic valve disease (moderate aortic stenosis and mild aortic regurgitation). He presented with a 3-month history of recurrent fever and general deterioration. Despite targeted, prolonged, combined antibiotic treatment with intravenous penicillin and gentamicin, surgery was eventually required. An aortic prosthetic valve implantation was performed with good results. In case of subacute endocarditis, especially when a causative organism proves difficult to detect, G. elegans should be considered. Identification is greatly enhanced by using polymerase chain reaction methods and this test should be considered in all cases of culture negative endocarditis.https://doi.org/10.1177/03000605221135173 |
| spellingShingle | Jana Deptová Laura Gombošová Marek Felšöci Eva Schréterová infective endocarditis: A case report Journal of International Medical Research |
| title | infective endocarditis: A case report |
| title_full | infective endocarditis: A case report |
| title_fullStr | infective endocarditis: A case report |
| title_full_unstemmed | infective endocarditis: A case report |
| title_short | infective endocarditis: A case report |
| title_sort | infective endocarditis a case report |
| url | https://doi.org/10.1177/03000605221135173 |
| work_keys_str_mv | AT janadeptova infectiveendocarditisacasereport AT lauragombosova infectiveendocarditisacasereport AT marekfelsoci infectiveendocarditisacasereport AT evaschreterova infectiveendocarditisacasereport |