Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction
Ischemic heart disease still represents a large burden on individuals and health care resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow-limiting obstruction in large–medium sized coronary arteries. However, clinical, angiographic and autoptic findings suggest...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/21/8118 |
| _version_ | 1797549222437847040 |
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| author | Paolo Severino Andrea D'Amato Mariateresa Pucci Fabio Infusino Francesco Adamo Lucia Ilaria Birtolo Lucrezia Netti Giulio Montefusco Cristina Chimenti Carlo Lavalle Viviana Maestrini Massimo Mancone William M. Chilian Francesco Fedele |
| author_facet | Paolo Severino Andrea D'Amato Mariateresa Pucci Fabio Infusino Francesco Adamo Lucia Ilaria Birtolo Lucrezia Netti Giulio Montefusco Cristina Chimenti Carlo Lavalle Viviana Maestrini Massimo Mancone William M. Chilian Francesco Fedele |
| author_sort | Paolo Severino |
| collection | DOAJ |
| description | Ischemic heart disease still represents a large burden on individuals and health care resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow-limiting obstruction in large–medium sized coronary arteries. However, clinical, angiographic and autoptic findings suggest a multifaceted pathophysiology for ischemic heart disease and just some cases are caused by severe or complicated atherosclerotic plaques. Currently there is no well-defined assessment of ischemic heart disease pathophysiology that satisfies all the observations and sometimes the underlying mechanism to everyday ischemic heart disease ward cases is misleading. In order to better examine this complicated disease and to provide future perspectives, it is important to know and analyze the pathophysiological mechanisms that underline it, because ischemic heart disease is not always determined by atherosclerotic plaque complication. Therefore, in order to have a more complete comprehension of ischemic heart disease we propose an overview of the available pathophysiological paradigms, from plaque activation to microvascular dysfunction. |
| first_indexed | 2024-03-10T15:11:33Z |
| format | Article |
| id | doaj.art-074c8b87c4c1477188bbe4eefac233c4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:11:33Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-074c8b87c4c1477188bbe4eefac233c42023-11-20T19:14:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012121811810.3390/ijms21218118Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular DysfunctionPaolo Severino0Andrea D'Amato1Mariateresa Pucci2Fabio Infusino3Francesco Adamo4Lucia Ilaria Birtolo5Lucrezia Netti6Giulio Montefusco7Cristina Chimenti8Carlo Lavalle9Viviana Maestrini10Massimo Mancone11William M. Chilian12Francesco Fedele13Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USADepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, ItalyIschemic heart disease still represents a large burden on individuals and health care resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow-limiting obstruction in large–medium sized coronary arteries. However, clinical, angiographic and autoptic findings suggest a multifaceted pathophysiology for ischemic heart disease and just some cases are caused by severe or complicated atherosclerotic plaques. Currently there is no well-defined assessment of ischemic heart disease pathophysiology that satisfies all the observations and sometimes the underlying mechanism to everyday ischemic heart disease ward cases is misleading. In order to better examine this complicated disease and to provide future perspectives, it is important to know and analyze the pathophysiological mechanisms that underline it, because ischemic heart disease is not always determined by atherosclerotic plaque complication. Therefore, in order to have a more complete comprehension of ischemic heart disease we propose an overview of the available pathophysiological paradigms, from plaque activation to microvascular dysfunction.https://www.mdpi.com/1422-0067/21/21/8118ischemic heart diseasemicrocirculationatherosclerosiscoronary blood flowmyocardial infarctionion channels |
| spellingShingle | Paolo Severino Andrea D'Amato Mariateresa Pucci Fabio Infusino Francesco Adamo Lucia Ilaria Birtolo Lucrezia Netti Giulio Montefusco Cristina Chimenti Carlo Lavalle Viviana Maestrini Massimo Mancone William M. Chilian Francesco Fedele Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction International Journal of Molecular Sciences ischemic heart disease microcirculation atherosclerosis coronary blood flow myocardial infarction ion channels |
| title | Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction |
| title_full | Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction |
| title_fullStr | Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction |
| title_full_unstemmed | Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction |
| title_short | Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction |
| title_sort | ischemic heart disease pathophysiology paradigms overview from plaque activation to microvascular dysfunction |
| topic | ischemic heart disease microcirculation atherosclerosis coronary blood flow myocardial infarction ion channels |
| url | https://www.mdpi.com/1422-0067/21/21/8118 |
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