Effect of transcranial magnetic stimulation in combination with citalopram on patients with post-stroke depression
BackgroundAmelioration of depression in patients with post-stroke depression (PSD) remains challenging.ObjectiveThe primary vision was to explore the effect of transcranial magnetic stimulation (TMS) in combination with citalopram on patients with PSD.MethodsOne hundred eligible patients who were di...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.962231/full |
| _version_ | 1811242678856187904 |
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| author | Zhen Zhu Hao-Xuan Zhu Shao-Wei Jing Xia-Zhen Li Xiao-Yan Yang Tu-Nan Luo Shuai Ye Xiao-Chun Ouyang Wei-Wei Song |
| author_facet | Zhen Zhu Hao-Xuan Zhu Shao-Wei Jing Xia-Zhen Li Xiao-Yan Yang Tu-Nan Luo Shuai Ye Xiao-Chun Ouyang Wei-Wei Song |
| author_sort | Zhen Zhu |
| collection | DOAJ |
| description | BackgroundAmelioration of depression in patients with post-stroke depression (PSD) remains challenging.ObjectiveThe primary vision was to explore the effect of transcranial magnetic stimulation (TMS) in combination with citalopram on patients with PSD.MethodsOne hundred eligible patients who were diagnosed with PSD were recruited and randomly assigned to the control group (n = 50) or the TMS group (n = 50). The controls were given citalopram (10 mg/d for consecutive 8 weeks), while, in addition to citalopram, patients in the TMS group were also given TMS at 5 Hz once a workday for 8 weeks. The primary outcome was patient depression status as reflected by 17-item Hamilton Rating Scale for Depression (HAMD-17) score, and the secondary outcome was patient neuropsychological score determined by Mini-Mental State Examination (MMSE) and Wisconsin Card Sorting Test (WCST).ResultsPatients treated with TMS in combination with citalopram had a drastic decrease in HAMD-17 score during treatment. Bigger changes in HAMD-17 score between baseline and 2 weeks as well as between baseline and 8 weeks in the TMS group were observed (P < 0.01). Patients in both groups had increased MMSE scores after treatment. Data of WCST revealed patients with TMS treatment completed more categories (P < 0.01) and had a lower RPP in comparison to patients in the control group (P < 0.0001). Additionally, TMS in combination with citalopram strikingly improved patients' MMSE scores when compared with those taking citalopram alone. Last, there was no striking difference in side effects between the two groups (P > 0.05).ConclusionOur study found TMS in combination with citalopram is conducive to improving depression status and neuropsychological function, which holds great promise for treating PSD. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-12T13:55:28Z |
| publishDate | 2022-10-01 |
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| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-07513982a7f948c7a1414a997f79ef212022-12-22T03:30:23ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-10-011610.3389/fnhum.2022.962231962231Effect of transcranial magnetic stimulation in combination with citalopram on patients with post-stroke depressionZhen Zhu0Hao-Xuan Zhu1Shao-Wei Jing2Xia-Zhen Li3Xiao-Yan Yang4Tu-Nan Luo5Shuai Ye6Xiao-Chun Ouyang7Wei-Wei Song8Rehabilitation Medicine Department, The 908th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Nanchang, ChinaDepartment of Neurology, The 908th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Nanchang, ChinaDepartment of Neurology, The 908th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Nanchang, ChinaRehabilitation Medicine Department, The 908th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Nanchang, ChinaDepartment of Neurology, The 908th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Nanchang, ChinaDepartment of Neurology, The 908th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Nanchang, ChinaDepartment of Neurology, Fuzong Clinical Medical College of Fujian Medical University (900 Hospital of the Joint Logistics Team), Fuzhou, ChinaDepartment of Neurology, The 908th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Nanchang, ChinaRehabilitation Medicine Department, The 908th Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Nanchang, ChinaBackgroundAmelioration of depression in patients with post-stroke depression (PSD) remains challenging.ObjectiveThe primary vision was to explore the effect of transcranial magnetic stimulation (TMS) in combination with citalopram on patients with PSD.MethodsOne hundred eligible patients who were diagnosed with PSD were recruited and randomly assigned to the control group (n = 50) or the TMS group (n = 50). The controls were given citalopram (10 mg/d for consecutive 8 weeks), while, in addition to citalopram, patients in the TMS group were also given TMS at 5 Hz once a workday for 8 weeks. The primary outcome was patient depression status as reflected by 17-item Hamilton Rating Scale for Depression (HAMD-17) score, and the secondary outcome was patient neuropsychological score determined by Mini-Mental State Examination (MMSE) and Wisconsin Card Sorting Test (WCST).ResultsPatients treated with TMS in combination with citalopram had a drastic decrease in HAMD-17 score during treatment. Bigger changes in HAMD-17 score between baseline and 2 weeks as well as between baseline and 8 weeks in the TMS group were observed (P < 0.01). Patients in both groups had increased MMSE scores after treatment. Data of WCST revealed patients with TMS treatment completed more categories (P < 0.01) and had a lower RPP in comparison to patients in the control group (P < 0.0001). Additionally, TMS in combination with citalopram strikingly improved patients' MMSE scores when compared with those taking citalopram alone. Last, there was no striking difference in side effects between the two groups (P > 0.05).ConclusionOur study found TMS in combination with citalopram is conducive to improving depression status and neuropsychological function, which holds great promise for treating PSD.https://www.frontiersin.org/articles/10.3389/fnhum.2022.962231/fulltranscranial magnetic stimulationcitaloprampost-stroke depressioncognitive functionneuropsychological score |
| spellingShingle | Zhen Zhu Hao-Xuan Zhu Shao-Wei Jing Xia-Zhen Li Xiao-Yan Yang Tu-Nan Luo Shuai Ye Xiao-Chun Ouyang Wei-Wei Song Effect of transcranial magnetic stimulation in combination with citalopram on patients with post-stroke depression Frontiers in Human Neuroscience transcranial magnetic stimulation citalopram post-stroke depression cognitive function neuropsychological score |
| title | Effect of transcranial magnetic stimulation in combination with citalopram on patients with post-stroke depression |
| title_full | Effect of transcranial magnetic stimulation in combination with citalopram on patients with post-stroke depression |
| title_fullStr | Effect of transcranial magnetic stimulation in combination with citalopram on patients with post-stroke depression |
| title_full_unstemmed | Effect of transcranial magnetic stimulation in combination with citalopram on patients with post-stroke depression |
| title_short | Effect of transcranial magnetic stimulation in combination with citalopram on patients with post-stroke depression |
| title_sort | effect of transcranial magnetic stimulation in combination with citalopram on patients with post stroke depression |
| topic | transcranial magnetic stimulation citalopram post-stroke depression cognitive function neuropsychological score |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.962231/full |
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