Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane
Di(3-thienyl)methanol (2) and di(3-thienyl)methane (3) have been synthesized and screened against the T98G (brain cancer) cell line. Treatment induced cell death (MTT and macro-colony assay), growth inhibition, cytogenetic damage (micronuclei formation), were studied as cellular response parameters....
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| Format: | Article |
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MDPI AG
2012-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/10/11456 |
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| author | Nagendra Kumar Kaushik Hong Seon Kim Young June Chae Young Nam Lee Gi-Chung Kwon Eun Ha Choi In Tae Kim |
| author_facet | Nagendra Kumar Kaushik Hong Seon Kim Young June Chae Young Nam Lee Gi-Chung Kwon Eun Ha Choi In Tae Kim |
| author_sort | Nagendra Kumar Kaushik |
| collection | DOAJ |
| description | Di(3-thienyl)methanol (2) and di(3-thienyl)methane (3) have been synthesized and screened against the T98G (brain cancer) cell line. Treatment induced cell death (MTT and macro-colony assay), growth inhibition, cytogenetic damage (micronuclei formation), were studied as cellular response parameters. Treatment with the compounds enhanced growth inhibition and cell death in a concentration dependent manner in both T98G and HEK (normal) cell lines. At higher concentrations (>20 µg/mL) the cytotoxic effects of the compounds were highly significant. The effect on clonogenic capacity and micronuclei formation observed after treatment of cells. Amongst the compounds, compound 2 exhibited potent activity against T98G brain cancer cells. Despite potent in vitro activity, both compounds exhibited less cytotoxicity against normal human HEK cells at all effective concentrations. |
| first_indexed | 2024-12-22T15:17:39Z |
| format | Article |
| id | doaj.art-0751c6780c084422a1231100d0695fbd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T15:17:39Z |
| publishDate | 2012-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0751c6780c084422a1231100d0695fbd2022-12-21T18:21:43ZengMDPI AGMolecules1420-30492012-09-011710114561146810.3390/molecules171011456Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methaneNagendra Kumar KaushikHong Seon KimYoung June ChaeYoung Nam LeeGi-Chung KwonEun Ha ChoiIn Tae KimDi(3-thienyl)methanol (2) and di(3-thienyl)methane (3) have been synthesized and screened against the T98G (brain cancer) cell line. Treatment induced cell death (MTT and macro-colony assay), growth inhibition, cytogenetic damage (micronuclei formation), were studied as cellular response parameters. Treatment with the compounds enhanced growth inhibition and cell death in a concentration dependent manner in both T98G and HEK (normal) cell lines. At higher concentrations (>20 µg/mL) the cytotoxic effects of the compounds were highly significant. The effect on clonogenic capacity and micronuclei formation observed after treatment of cells. Amongst the compounds, compound 2 exhibited potent activity against T98G brain cancer cells. Despite potent in vitro activity, both compounds exhibited less cytotoxicity against normal human HEK cells at all effective concentrations.http://www.mdpi.com/1420-3049/17/10/11456thienyl derivativesT98G gliomasHEK cells |
| spellingShingle | Nagendra Kumar Kaushik Hong Seon Kim Young June Chae Young Nam Lee Gi-Chung Kwon Eun Ha Choi In Tae Kim Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane Molecules thienyl derivatives T98G gliomas HEK cells |
| title | Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane |
| title_full | Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane |
| title_fullStr | Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane |
| title_full_unstemmed | Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane |
| title_short | Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane |
| title_sort | synthesis and anticancer activity of di 3 thienyl methanol and di 3 thienyl methane |
| topic | thienyl derivatives T98G gliomas HEK cells |
| url | http://www.mdpi.com/1420-3049/17/10/11456 |
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