Current Trends and Limitations in Dengue Antiviral Research
Dengue is the most prevalent arthropod-borne viral disease worldwide and affects approximately 2.5 billion people living in over 100 countries. Increasing geographic expansion of <i>Aedes aegypti</i> mosquitoes (which transmit the virus) has made dengue a global health concern. There are...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/6/4/180 |
| _version_ | 1797500144506109952 |
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| author | Juliet O. Obi Hernando Gutiérrez-Barbosa Joel V. Chua Daniel J. Deredge |
| author_facet | Juliet O. Obi Hernando Gutiérrez-Barbosa Joel V. Chua Daniel J. Deredge |
| author_sort | Juliet O. Obi |
| collection | DOAJ |
| description | Dengue is the most prevalent arthropod-borne viral disease worldwide and affects approximately 2.5 billion people living in over 100 countries. Increasing geographic expansion of <i>Aedes aegypti</i> mosquitoes (which transmit the virus) has made dengue a global health concern. There are currently no approved antivirals available to treat dengue, and the only approved vaccine used in some countries is limited to seropositive patients. Treatment of dengue, therefore, remains largely supportive to date; hence, research efforts are being intensified for the development of antivirals. The nonstructural proteins, 3 and 5 (NS3 and NS5), have been the major targets for dengue antiviral development due to their indispensable enzymatic and biological functions in the viral replication process. NS5 is the largest and most conserved nonstructural protein encoded by flaviviruses. Its multifunctionality makes it an attractive target for antiviral development, but research efforts have, this far, not resulted in the successful development of an antiviral targeting NS5. Increase in structural insights into the dengue NS5 protein will accelerate drug discovery efforts focused on NS5 as an antiviral target. In this review, we will give an overview of the current state of therapeutic development, with a focus on NS5 as a therapeutic target against dengue. |
| first_indexed | 2024-03-10T03:57:39Z |
| format | Article |
| id | doaj.art-0752c182e2c34c55a7ba779a08ed2a9a |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T03:57:39Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-0752c182e2c34c55a7ba779a08ed2a9a2023-11-23T10:51:45ZengMDPI AGTropical Medicine and Infectious Disease2414-63662021-09-016418010.3390/tropicalmed6040180Current Trends and Limitations in Dengue Antiviral ResearchJuliet O. Obi0Hernando Gutiérrez-Barbosa1Joel V. Chua2Daniel J. Deredge3Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USAInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USAInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USADengue is the most prevalent arthropod-borne viral disease worldwide and affects approximately 2.5 billion people living in over 100 countries. Increasing geographic expansion of <i>Aedes aegypti</i> mosquitoes (which transmit the virus) has made dengue a global health concern. There are currently no approved antivirals available to treat dengue, and the only approved vaccine used in some countries is limited to seropositive patients. Treatment of dengue, therefore, remains largely supportive to date; hence, research efforts are being intensified for the development of antivirals. The nonstructural proteins, 3 and 5 (NS3 and NS5), have been the major targets for dengue antiviral development due to their indispensable enzymatic and biological functions in the viral replication process. NS5 is the largest and most conserved nonstructural protein encoded by flaviviruses. Its multifunctionality makes it an attractive target for antiviral development, but research efforts have, this far, not resulted in the successful development of an antiviral targeting NS5. Increase in structural insights into the dengue NS5 protein will accelerate drug discovery efforts focused on NS5 as an antiviral target. In this review, we will give an overview of the current state of therapeutic development, with a focus on NS5 as a therapeutic target against dengue.https://www.mdpi.com/2414-6366/6/4/180antiviral targetsdengue virusflavivirusNS5nucleoside inhibitorsnon-nucleoside inhibitors |
| spellingShingle | Juliet O. Obi Hernando Gutiérrez-Barbosa Joel V. Chua Daniel J. Deredge Current Trends and Limitations in Dengue Antiviral Research Tropical Medicine and Infectious Disease antiviral targets dengue virus flavivirus NS5 nucleoside inhibitors non-nucleoside inhibitors |
| title | Current Trends and Limitations in Dengue Antiviral Research |
| title_full | Current Trends and Limitations in Dengue Antiviral Research |
| title_fullStr | Current Trends and Limitations in Dengue Antiviral Research |
| title_full_unstemmed | Current Trends and Limitations in Dengue Antiviral Research |
| title_short | Current Trends and Limitations in Dengue Antiviral Research |
| title_sort | current trends and limitations in dengue antiviral research |
| topic | antiviral targets dengue virus flavivirus NS5 nucleoside inhibitors non-nucleoside inhibitors |
| url | https://www.mdpi.com/2414-6366/6/4/180 |
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