Analysis of risk factors associated with secondary open-angle glaucoma in Posner-Schlossman syndrome: A retrospective case-control study
BackgroundPosner-Schlossman syndrome (PSS) is a relatively rare cause of chronic secondary open-angle glaucoma (OAG), but the exact cause is unknown. This study aimed to determine potential risk factors for OAG secondary to PSS and to provide a basis for early intervention in the development of PSS....
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1064449/full |
| _version_ | 1797957571282206720 |
|---|---|
| author | Jiajun Li Jiajun Li Yuke Ji Yuke Ji Weihua Yang Yujia Yao Yujia Yao Suyu Wang Suyu Wang Ziran Zhang Ziran Zhang Jin Yao Jin Yao Keran Li Keran Li |
| author_facet | Jiajun Li Jiajun Li Yuke Ji Yuke Ji Weihua Yang Yujia Yao Yujia Yao Suyu Wang Suyu Wang Ziran Zhang Ziran Zhang Jin Yao Jin Yao Keran Li Keran Li |
| author_sort | Jiajun Li |
| collection | DOAJ |
| description | BackgroundPosner-Schlossman syndrome (PSS) is a relatively rare cause of chronic secondary open-angle glaucoma (OAG), but the exact cause is unknown. This study aimed to determine potential risk factors for OAG secondary to PSS and to provide a basis for early intervention in the development of PSS.MethodsThis was a retrospective case-control study. Nine cases diagnosed with PSS and seven cases diagnosed with OAG secondary to PSS were selected and their aqueous humor assays at the first occurrence of PSS were collected. Clinical characteristics including age, sex, disease duration, eye laterality, baseline visual acuity, maximum IOP, corneal endothelial cell density, visual field, retinal nerve fiber layer thickness, cup-to-disk ratio, keratic precipitates, anterior chamber inflammation, and aqueous humor cytokine assay results were compared between the two groups.ResultsThe cytomegalovirus (CMV) positivity was 55.60% in patients with PSS and 100% in patients with OAG secondary to PSS. Corneal endothelial cell density was lower in patients with CMV-positive PSS (p = 0.0116). Concentrations of basic fibroblast growth factor (bFGF), interleukin (IL)-6, and vascular cell adhesion molecule (VCAM) in patients with PSS and IL-8, IL-6, and VCAM in patients with OAG secondary to PSS were higher than standard reference values; and IL-8 concentration was significantly higher in patients with OAG secondary to PSS (p = 0.0229). There were significant positive correlations between IL-8 and IL-6, IL-6 and VCAM (p = 0.0304, p = 0.0172) and a significant negative correlation between bFGF and vascular endothelial growth factor (VEGF) (p = 0.0497). Simultaneous increase of IL-8 and IL-6 concentration levels could be used as a cytokine indicator to predict secondary OAG in patients with PSS (p = 0.0095).ConclusionSimultaneous increase of IL-8 and IL-6 concentrations may be an important cause of accelerated secondary OAG in patients with PSS, with IL-8 playing a more critical role. IL-8 and IL-6 may be more reliable cytokine markers for predicting secondary OAG in PSS, However, the high possibility of secondary OAG in patients with CMV-positive PSS should not be ignored. Regulation of IL-8 and IL-6 levels may be a new strategy of preventing OAG secondary to PSS. |
| first_indexed | 2024-04-11T00:07:16Z |
| format | Article |
| id | doaj.art-075407c122c548c4b26e579c4ace017a |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T00:07:16Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-075407c122c548c4b26e579c4ace017a2023-01-09T09:50:38ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-01-01910.3389/fmed.2022.10644491064449Analysis of risk factors associated with secondary open-angle glaucoma in Posner-Schlossman syndrome: A retrospective case-control studyJiajun Li0Jiajun Li1Yuke Ji2Yuke Ji3Weihua Yang4Yujia Yao5Yujia Yao6Suyu Wang7Suyu Wang8Ziran Zhang9Ziran Zhang10Jin Yao11Jin Yao12Keran Li13Keran Li14The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing, ChinaThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing, ChinaThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, ChinaThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing, ChinaThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing, ChinaThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing, ChinaThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing, ChinaThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing, ChinaBackgroundPosner-Schlossman syndrome (PSS) is a relatively rare cause of chronic secondary open-angle glaucoma (OAG), but the exact cause is unknown. This study aimed to determine potential risk factors for OAG secondary to PSS and to provide a basis for early intervention in the development of PSS.MethodsThis was a retrospective case-control study. Nine cases diagnosed with PSS and seven cases diagnosed with OAG secondary to PSS were selected and their aqueous humor assays at the first occurrence of PSS were collected. Clinical characteristics including age, sex, disease duration, eye laterality, baseline visual acuity, maximum IOP, corneal endothelial cell density, visual field, retinal nerve fiber layer thickness, cup-to-disk ratio, keratic precipitates, anterior chamber inflammation, and aqueous humor cytokine assay results were compared between the two groups.ResultsThe cytomegalovirus (CMV) positivity was 55.60% in patients with PSS and 100% in patients with OAG secondary to PSS. Corneal endothelial cell density was lower in patients with CMV-positive PSS (p = 0.0116). Concentrations of basic fibroblast growth factor (bFGF), interleukin (IL)-6, and vascular cell adhesion molecule (VCAM) in patients with PSS and IL-8, IL-6, and VCAM in patients with OAG secondary to PSS were higher than standard reference values; and IL-8 concentration was significantly higher in patients with OAG secondary to PSS (p = 0.0229). There were significant positive correlations between IL-8 and IL-6, IL-6 and VCAM (p = 0.0304, p = 0.0172) and a significant negative correlation between bFGF and vascular endothelial growth factor (VEGF) (p = 0.0497). Simultaneous increase of IL-8 and IL-6 concentration levels could be used as a cytokine indicator to predict secondary OAG in patients with PSS (p = 0.0095).ConclusionSimultaneous increase of IL-8 and IL-6 concentrations may be an important cause of accelerated secondary OAG in patients with PSS, with IL-8 playing a more critical role. IL-8 and IL-6 may be more reliable cytokine markers for predicting secondary OAG in PSS, However, the high possibility of secondary OAG in patients with CMV-positive PSS should not be ignored. Regulation of IL-8 and IL-6 levels may be a new strategy of preventing OAG secondary to PSS.https://www.frontiersin.org/articles/10.3389/fmed.2022.1064449/fullPosner-Schlossman syndromeopen-angle glaucomaanterior uveitisintraocular pressureinterleukincytomegalovirus (CMV) |
| spellingShingle | Jiajun Li Jiajun Li Yuke Ji Yuke Ji Weihua Yang Yujia Yao Yujia Yao Suyu Wang Suyu Wang Ziran Zhang Ziran Zhang Jin Yao Jin Yao Keran Li Keran Li Analysis of risk factors associated with secondary open-angle glaucoma in Posner-Schlossman syndrome: A retrospective case-control study Frontiers in Medicine Posner-Schlossman syndrome open-angle glaucoma anterior uveitis intraocular pressure interleukin cytomegalovirus (CMV) |
| title | Analysis of risk factors associated with secondary open-angle glaucoma in Posner-Schlossman syndrome: A retrospective case-control study |
| title_full | Analysis of risk factors associated with secondary open-angle glaucoma in Posner-Schlossman syndrome: A retrospective case-control study |
| title_fullStr | Analysis of risk factors associated with secondary open-angle glaucoma in Posner-Schlossman syndrome: A retrospective case-control study |
| title_full_unstemmed | Analysis of risk factors associated with secondary open-angle glaucoma in Posner-Schlossman syndrome: A retrospective case-control study |
| title_short | Analysis of risk factors associated with secondary open-angle glaucoma in Posner-Schlossman syndrome: A retrospective case-control study |
| title_sort | analysis of risk factors associated with secondary open angle glaucoma in posner schlossman syndrome a retrospective case control study |
| topic | Posner-Schlossman syndrome open-angle glaucoma anterior uveitis intraocular pressure interleukin cytomegalovirus (CMV) |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1064449/full |
| work_keys_str_mv | AT jiajunli analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT jiajunli analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT yukeji analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT yukeji analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT weihuayang analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT yujiayao analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT yujiayao analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT suyuwang analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT suyuwang analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT ziranzhang analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT ziranzhang analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT jinyao analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT jinyao analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT keranli analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy AT keranli analysisofriskfactorsassociatedwithsecondaryopenangleglaucomainposnerschlossmansyndromearetrospectivecasecontrolstudy |