Intracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced Stress
L-Pipecolic acid is an intermediate of L-lysine catabolism. Its central injection exerted a hypnotic effect on the brain, which was partially mediated by the activation of γ-aminobutyric acid-A and γ-aminobutyric acid-B receptors. L-Proline has also been shown to exert a similar effect on N-methyl-D...
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| Format: | Article |
| Language: | English |
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Japan Poultry Science Association
2020-01-01
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| Series: | The Journal of Poultry Science |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpsa/57/1/57_0190067/_html/-char/en |
| _version_ | 1827938983153238016 |
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| author | Asako Shigemura Vishwajit S. Chowdhury Mitsuhiro Furuse |
| author_facet | Asako Shigemura Vishwajit S. Chowdhury Mitsuhiro Furuse |
| author_sort | Asako Shigemura |
| collection | DOAJ |
| description | L-Pipecolic acid is an intermediate of L-lysine catabolism. Its central injection exerted a hypnotic effect on the brain, which was partially mediated by the activation of γ-aminobutyric acid-A and γ-aminobutyric acid-B receptors. L-Proline has also been shown to exert a similar effect on N-methyl-D-aspartate receptors. Furthermore, L-pipecolic acid is known as L-homoproline, and both L-pipecolic acid and L-proline belong to the imino acid group; therefore, it is plausible that they share certain commonalities, including similar functions. However, the role of N-methyl-D-aspartate receptors with respect to the effects of L-pipecolic acid has not been examined yet. In the present study, the relationship between N-methyl-D-aspartate receptors and the central function of L-pipecolic acid was investigated in neonatal chicks. The behavioral postures for active wakefulness and standing/sitting motionless with eyes opened were significantly affected after intracerebroventricular injection of L-pipecolic acid; whereas, sitting motionless with head drooped (sleeping posture) was significantly enhanced. However, the N-methyl-D-aspartate receptor antagonist, MK-801, did not affect these changes. In conclusion, the central administration of L-pipecolic acid did not exert hypnotic effects through the activation of N-methyl-D-aspartate receptors in neonatal chicks. These results suggest that the imino group is not a determinant for activating N-methyl-D-aspartate receptors. |
| first_indexed | 2024-03-13T08:46:41Z |
| format | Article |
| id | doaj.art-07551224d94842ddb3992cc99dbcd80d |
| institution | Directory Open Access Journal |
| issn | 1346-7395 1349-0486 |
| language | English |
| last_indexed | 2024-03-13T08:46:41Z |
| publishDate | 2020-01-01 |
| publisher | Japan Poultry Science Association |
| record_format | Article |
| series | The Journal of Poultry Science |
| spelling | doaj.art-07551224d94842ddb3992cc99dbcd80d2023-05-30T01:20:30ZengJapan Poultry Science AssociationThe Journal of Poultry Science1346-73951349-04862020-01-01571848710.2141/jpsa.0190067jpsaIntracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced StressAsako Shigemura0Vishwajit S. Chowdhury1Mitsuhiro Furuse2Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu UniversityLaboratory of Stress Physiology and Metabolism, Faculty of Arts and Science, Kyushu UniversityLaboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu UniversityL-Pipecolic acid is an intermediate of L-lysine catabolism. Its central injection exerted a hypnotic effect on the brain, which was partially mediated by the activation of γ-aminobutyric acid-A and γ-aminobutyric acid-B receptors. L-Proline has also been shown to exert a similar effect on N-methyl-D-aspartate receptors. Furthermore, L-pipecolic acid is known as L-homoproline, and both L-pipecolic acid and L-proline belong to the imino acid group; therefore, it is plausible that they share certain commonalities, including similar functions. However, the role of N-methyl-D-aspartate receptors with respect to the effects of L-pipecolic acid has not been examined yet. In the present study, the relationship between N-methyl-D-aspartate receptors and the central function of L-pipecolic acid was investigated in neonatal chicks. The behavioral postures for active wakefulness and standing/sitting motionless with eyes opened were significantly affected after intracerebroventricular injection of L-pipecolic acid; whereas, sitting motionless with head drooped (sleeping posture) was significantly enhanced. However, the N-methyl-D-aspartate receptor antagonist, MK-801, did not affect these changes. In conclusion, the central administration of L-pipecolic acid did not exert hypnotic effects through the activation of N-methyl-D-aspartate receptors in neonatal chicks. These results suggest that the imino group is not a determinant for activating N-methyl-D-aspartate receptors.https://www.jstage.jst.go.jp/article/jpsa/57/1/57_0190067/_html/-char/enbrainchickshypnotic effectl-pipecolic acidnmda receptor |
| spellingShingle | Asako Shigemura Vishwajit S. Chowdhury Mitsuhiro Furuse Intracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced Stress The Journal of Poultry Science brain chicks hypnotic effect l-pipecolic acid nmda receptor |
| title | Intracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced Stress |
| title_full | Intracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced Stress |
| title_fullStr | Intracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced Stress |
| title_full_unstemmed | Intracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced Stress |
| title_short | Intracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced Stress |
| title_sort | intracerebroventricular injection of l pipecolic acid exerts hypnotic effects without activating nmda receptors in neonatal chicks under social isolation induced stress |
| topic | brain chicks hypnotic effect l-pipecolic acid nmda receptor |
| url | https://www.jstage.jst.go.jp/article/jpsa/57/1/57_0190067/_html/-char/en |
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