Binge eating disorder, frequency of depression, and systemic inflammatory state in individuals with obesity – A cross sectional study
ABSTRACT Objective: Binge eating disorder (BED) is the most prevalent eating disorder in individuals with obesity. Its association with factors that control hunger and satiety has not yet been elucidated. We evaluated whether levels of inflammatory markers, frequency of psychiatric comorbidities, a...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2022-07-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005008204&tlng=en |
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| author | Nelson do Rosário Caldas Valeria Bender Braulio Marco Antônio Alves Brasil Valeria Cristina Soares Furtado Denise Pires de Carvalho Ervin Michelstaedter Cotrik Joana Rodrigues Dantas Lenita Zajdenverg |
| author_facet | Nelson do Rosário Caldas Valeria Bender Braulio Marco Antônio Alves Brasil Valeria Cristina Soares Furtado Denise Pires de Carvalho Ervin Michelstaedter Cotrik Joana Rodrigues Dantas Lenita Zajdenverg |
| author_sort | Nelson do Rosário Caldas |
| collection | DOAJ |
| description | ABSTRACT Objective: Binge eating disorder (BED) is the most prevalent eating disorder in individuals with obesity. Its association with factors that control hunger and satiety has not yet been elucidated. We evaluated whether levels of inflammatory markers, frequency of psychiatric comorbidities, and appetite-related hormones levels differ between individuals with obesity with and without BED. Materials and methods: The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-5 – Clinician Version (SCID-5-CV), Binge Eating Scale, and Hospital Anxiety and Depression Scale were evaluated in 39 individuals with obesity. Plasma levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), leptin, ghrelin, and glucagon-like peptide-1 (GLP-1) were measured. Results: Individuals of the BED group exhibited significantly higher percentages of altered eating patterns (hyperphagia, bingeing, post-dinner eating, feeling “stuffed”, and emotional eating), higher depressive symptom scores and levels of leptin, CRP, and TNF-α, compared to those from the non-BED group. Logistic regression showed that BED was independently associated with depressive symptoms and CRP levels. Conclusions: Individuals with obesity and BED showed greater psychiatric comorbidity, worse eating patterns and worse inflammatory profile than those without BED. BED should be assessed as an indicator of clinical severity in patients with obesity. |
| first_indexed | 2024-04-13T21:00:34Z |
| format | Article |
| id | doaj.art-0755bd82c952442a83adb5d49cc396a1 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-13T21:00:34Z |
| publishDate | 2022-07-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-0755bd82c952442a83adb5d49cc396a12022-12-22T02:30:09ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922022-07-0110.20945/2359-3997000000489Binge eating disorder, frequency of depression, and systemic inflammatory state in individuals with obesity – A cross sectional studyNelson do Rosário Caldashttps://orcid.org/0000-0002-3139-5266Valeria Bender Brauliohttps://orcid.org/0000-0002-2198-4059Marco Antônio Alves Brasilhttps://orcid.org/0000-0002-0548-1590Valeria Cristina Soares Furtadohttps://orcid.org/0000-0002-9120-6076Denise Pires de Carvalhohttps://orcid.org/0000-0001-6933-6424Ervin Michelstaedter Cotrikhttps://orcid.org/0000-0001-7609-2528Joana Rodrigues Dantashttps://orcid.org/0000-0002-6088-2813Lenita Zajdenverghttps://orcid.org/0000-0002-1579-3299ABSTRACT Objective: Binge eating disorder (BED) is the most prevalent eating disorder in individuals with obesity. Its association with factors that control hunger and satiety has not yet been elucidated. We evaluated whether levels of inflammatory markers, frequency of psychiatric comorbidities, and appetite-related hormones levels differ between individuals with obesity with and without BED. Materials and methods: The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-5 – Clinician Version (SCID-5-CV), Binge Eating Scale, and Hospital Anxiety and Depression Scale were evaluated in 39 individuals with obesity. Plasma levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), leptin, ghrelin, and glucagon-like peptide-1 (GLP-1) were measured. Results: Individuals of the BED group exhibited significantly higher percentages of altered eating patterns (hyperphagia, bingeing, post-dinner eating, feeling “stuffed”, and emotional eating), higher depressive symptom scores and levels of leptin, CRP, and TNF-α, compared to those from the non-BED group. Logistic regression showed that BED was independently associated with depressive symptoms and CRP levels. Conclusions: Individuals with obesity and BED showed greater psychiatric comorbidity, worse eating patterns and worse inflammatory profile than those without BED. BED should be assessed as an indicator of clinical severity in patients with obesity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005008204&tlng=enBinge eating disorderobesitydepressionleptininflammation |
| spellingShingle | Nelson do Rosário Caldas Valeria Bender Braulio Marco Antônio Alves Brasil Valeria Cristina Soares Furtado Denise Pires de Carvalho Ervin Michelstaedter Cotrik Joana Rodrigues Dantas Lenita Zajdenverg Binge eating disorder, frequency of depression, and systemic inflammatory state in individuals with obesity – A cross sectional study Archives of Endocrinology and Metabolism Binge eating disorder obesity depression leptin inflammation |
| title | Binge eating disorder, frequency of depression, and systemic inflammatory state in individuals with obesity – A cross sectional study |
| title_full | Binge eating disorder, frequency of depression, and systemic inflammatory state in individuals with obesity – A cross sectional study |
| title_fullStr | Binge eating disorder, frequency of depression, and systemic inflammatory state in individuals with obesity – A cross sectional study |
| title_full_unstemmed | Binge eating disorder, frequency of depression, and systemic inflammatory state in individuals with obesity – A cross sectional study |
| title_short | Binge eating disorder, frequency of depression, and systemic inflammatory state in individuals with obesity – A cross sectional study |
| title_sort | binge eating disorder frequency of depression and systemic inflammatory state in individuals with obesity a cross sectional study |
| topic | Binge eating disorder obesity depression leptin inflammation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005008204&tlng=en |
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