Nanoparticle-mediated synergistic chemoimmunotherapy for tailoring cancer therapy: recent advances and perspectives
Abstract Nowadays, a potent challenge in cancer treatment is considered the lack of efficacious strategy, which has not been able to significantly reduce mortality. Chemoimmunotherapy (CIT) as a promising approach in both for the first-line and relapsed therapy demonstrated particular benefit from t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-04-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-00861-0 |
| _version_ | 1811186589647241216 |
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| author | Rafieh Bagherifar Seyed Hossein Kiaie Zahra Hatami Armin Ahmadi Abdolvahid Sadeghnejad Behzad Baradaran Reza Jafari Yousef Javadzadeh |
| author_facet | Rafieh Bagherifar Seyed Hossein Kiaie Zahra Hatami Armin Ahmadi Abdolvahid Sadeghnejad Behzad Baradaran Reza Jafari Yousef Javadzadeh |
| author_sort | Rafieh Bagherifar |
| collection | DOAJ |
| description | Abstract Nowadays, a potent challenge in cancer treatment is considered the lack of efficacious strategy, which has not been able to significantly reduce mortality. Chemoimmunotherapy (CIT) as a promising approach in both for the first-line and relapsed therapy demonstrated particular benefit from two key gating strategies, including chemotherapy and immunotherapy to cancer therapy; therefore, the discernment of their participation and role of potential synergies in CIT approach is determinant. In this study, in addition to balancing the pros and cons of CIT with the challenges of each of two main strategies, the recent advances in the cancer CIT have been discussed. Additionally, immunotherapeutic strategies and the immunomodulation effect induced by chemotherapy, which boosts CIT have been brought up. Finally, harnessing and development of the nanoparticles, which mediated CIT have expatiated in detail. |
| first_indexed | 2024-04-11T13:49:03Z |
| format | Article |
| id | doaj.art-0755d881300a49a68c4c9d47732c5192 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T13:49:03Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-0755d881300a49a68c4c9d47732c51922022-12-22T04:20:48ZengBMCJournal of Nanobiotechnology1477-31552021-04-0119111810.1186/s12951-021-00861-0Nanoparticle-mediated synergistic chemoimmunotherapy for tailoring cancer therapy: recent advances and perspectivesRafieh Bagherifar0Seyed Hossein Kiaie1Zahra Hatami2Armin Ahmadi3Abdolvahid Sadeghnejad4Behzad Baradaran5Reza Jafari6Yousef Javadzadeh7Student Research Committee, Tabriz University of Medical SciencesStudent Research Committee, Tabriz University of Medical SciencesDepartment of Immunology, Faculty of Medical Sciences, Tarbiat Modares UniversityDepartment of Chemical & Materials Engineering, The University of Alabama in HuntsvilleCancer Research Center, Semnan University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesSolid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical SciencesBiotechnology Research Center, and Faculty of Pharmacy, Tabriz University of Medical ScienceAbstract Nowadays, a potent challenge in cancer treatment is considered the lack of efficacious strategy, which has not been able to significantly reduce mortality. Chemoimmunotherapy (CIT) as a promising approach in both for the first-line and relapsed therapy demonstrated particular benefit from two key gating strategies, including chemotherapy and immunotherapy to cancer therapy; therefore, the discernment of their participation and role of potential synergies in CIT approach is determinant. In this study, in addition to balancing the pros and cons of CIT with the challenges of each of two main strategies, the recent advances in the cancer CIT have been discussed. Additionally, immunotherapeutic strategies and the immunomodulation effect induced by chemotherapy, which boosts CIT have been brought up. Finally, harnessing and development of the nanoparticles, which mediated CIT have expatiated in detail.https://doi.org/10.1186/s12951-021-00861-0ChemoimmunotherapyChemotherapyImmunotherapyNanoparticlesMonoclonal antibodyCytokines |
| spellingShingle | Rafieh Bagherifar Seyed Hossein Kiaie Zahra Hatami Armin Ahmadi Abdolvahid Sadeghnejad Behzad Baradaran Reza Jafari Yousef Javadzadeh Nanoparticle-mediated synergistic chemoimmunotherapy for tailoring cancer therapy: recent advances and perspectives Journal of Nanobiotechnology Chemoimmunotherapy Chemotherapy Immunotherapy Nanoparticles Monoclonal antibody Cytokines |
| title | Nanoparticle-mediated synergistic chemoimmunotherapy for tailoring cancer therapy: recent advances and perspectives |
| title_full | Nanoparticle-mediated synergistic chemoimmunotherapy for tailoring cancer therapy: recent advances and perspectives |
| title_fullStr | Nanoparticle-mediated synergistic chemoimmunotherapy for tailoring cancer therapy: recent advances and perspectives |
| title_full_unstemmed | Nanoparticle-mediated synergistic chemoimmunotherapy for tailoring cancer therapy: recent advances and perspectives |
| title_short | Nanoparticle-mediated synergistic chemoimmunotherapy for tailoring cancer therapy: recent advances and perspectives |
| title_sort | nanoparticle mediated synergistic chemoimmunotherapy for tailoring cancer therapy recent advances and perspectives |
| topic | Chemoimmunotherapy Chemotherapy Immunotherapy Nanoparticles Monoclonal antibody Cytokines |
| url | https://doi.org/10.1186/s12951-021-00861-0 |
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