Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer
Abstract Background The histological grade is an important factor in the prognosis of invasive breast cancer and is vital to accurately identify the histological grade and reclassify of Grade2 status in breast cancer patients. Methods In this study, data were collected from 556 invasive breast cance...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-024-12069-0 |
| _version_ | 1797266743467442176 |
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| author | Deyong Kang Chuan Wang Zhonghua Han Liqin Zheng Wenhui Guo Fangmeng Fu Lida Qiu Xiahui Han Jiajia He Lianhuang Li Jianxin Chen |
| author_facet | Deyong Kang Chuan Wang Zhonghua Han Liqin Zheng Wenhui Guo Fangmeng Fu Lida Qiu Xiahui Han Jiajia He Lianhuang Li Jianxin Chen |
| author_sort | Deyong Kang |
| collection | DOAJ |
| description | Abstract Background The histological grade is an important factor in the prognosis of invasive breast cancer and is vital to accurately identify the histological grade and reclassify of Grade2 status in breast cancer patients. Methods In this study, data were collected from 556 invasive breast cancer patients, and then randomly divided into training cohort (n = 335) and validation cohort (n = 221). All patients were divided into actual low risk group (Grade1) and high risk group (Grade2/3) based on traditional histological grade, and tumor-infiltrating lymphocyte score (TILs-score) obtained from multiphoton images, and the TILs assessment method proposed by International Immuno-Oncology Biomarker Working Group (TILs-WG) were also used to differentiate between high risk group and low risk group of histological grade in patients with invasive breast cancer. Furthermore, TILs-score was used to reclassify Grade2 (G2) into G2 /Low risk and G2/High risk. The coefficients for each TILs in the training cohort were retrieved using ridge regression and TILs-score was created based on the coefficients of the three kinds of TILs. Results Statistical analysis shows that TILs-score is significantly correlated with histological grade, and is an independent predictor of histological grade (odds ratio [OR], 2.548; 95%CI, 1.648–3.941; P < 0.0001), but TILs-WG is not an independent predictive factor for grade (P > 0.05 in the univariate analysis). Moreover, the risk of G2/High risk group is higher than that of G2/Low risk group, and the survival rate of patients with G2/Low risk is similar to that of Grade1, while the survival rate of patients with G2/High risk is even worse than that of patients with G3. Conclusion Our results suggest that TILs-score can be used to predict the histological grade of breast cancer and potentially to guide the therapeutic management of breast cancer patients. |
| first_indexed | 2024-04-25T01:05:32Z |
| format | Article |
| id | doaj.art-07583ab960ae4fd79682f8b0a42abe84 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-25T01:05:32Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-07583ab960ae4fd79682f8b0a42abe842024-03-10T12:14:43ZengBMCBMC Cancer1471-24072024-03-0124111310.1186/s12885-024-12069-0Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancerDeyong Kang0Chuan Wang1Zhonghua Han2Liqin Zheng3Wenhui Guo4Fangmeng Fu5Lida Qiu6Xiahui Han7Jiajia He8Lianhuang Li9Jianxin Chen10Department of Pathology, Fujian Medical University Union HospitalBreast Surgery Ward, Department of General Surgery, Fujian Medical University Union HospitalBreast Surgery Ward, Department of General Surgery, Fujian Medical University Union HospitalKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, College of Photonic and Electronic Engineering, Fujian Normal UniversityBreast Surgery Ward, Department of General Surgery, Fujian Medical University Union HospitalBreast Surgery Ward, Department of General Surgery, Fujian Medical University Union HospitalCollege of Physics and Electronic Information Engineering, Minjiang UniversityKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, College of Photonic and Electronic Engineering, Fujian Normal UniversitySchool of Science, Jimei UniversityKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, College of Photonic and Electronic Engineering, Fujian Normal UniversityKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, College of Photonic and Electronic Engineering, Fujian Normal UniversityAbstract Background The histological grade is an important factor in the prognosis of invasive breast cancer and is vital to accurately identify the histological grade and reclassify of Grade2 status in breast cancer patients. Methods In this study, data were collected from 556 invasive breast cancer patients, and then randomly divided into training cohort (n = 335) and validation cohort (n = 221). All patients were divided into actual low risk group (Grade1) and high risk group (Grade2/3) based on traditional histological grade, and tumor-infiltrating lymphocyte score (TILs-score) obtained from multiphoton images, and the TILs assessment method proposed by International Immuno-Oncology Biomarker Working Group (TILs-WG) were also used to differentiate between high risk group and low risk group of histological grade in patients with invasive breast cancer. Furthermore, TILs-score was used to reclassify Grade2 (G2) into G2 /Low risk and G2/High risk. The coefficients for each TILs in the training cohort were retrieved using ridge regression and TILs-score was created based on the coefficients of the three kinds of TILs. Results Statistical analysis shows that TILs-score is significantly correlated with histological grade, and is an independent predictor of histological grade (odds ratio [OR], 2.548; 95%CI, 1.648–3.941; P < 0.0001), but TILs-WG is not an independent predictive factor for grade (P > 0.05 in the univariate analysis). Moreover, the risk of G2/High risk group is higher than that of G2/Low risk group, and the survival rate of patients with G2/Low risk is similar to that of Grade1, while the survival rate of patients with G2/High risk is even worse than that of patients with G3. Conclusion Our results suggest that TILs-score can be used to predict the histological grade of breast cancer and potentially to guide the therapeutic management of breast cancer patients.https://doi.org/10.1186/s12885-024-12069-0Tumor-infiltrating lymphocyte scoreMultiphoton microscopyHistological grade |
| spellingShingle | Deyong Kang Chuan Wang Zhonghua Han Liqin Zheng Wenhui Guo Fangmeng Fu Lida Qiu Xiahui Han Jiajia He Lianhuang Li Jianxin Chen Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer BMC Cancer Tumor-infiltrating lymphocyte score Multiphoton microscopy Histological grade |
| title | Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer |
| title_full | Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer |
| title_fullStr | Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer |
| title_full_unstemmed | Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer |
| title_short | Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer |
| title_sort | exploration of the relationship between tumor infiltrating lymphocyte score and histological grade in breast cancer |
| topic | Tumor-infiltrating lymphocyte score Multiphoton microscopy Histological grade |
| url | https://doi.org/10.1186/s12885-024-12069-0 |
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