Intracranial Mass Lesion Due to Fungal Infection: A Case Series and Review of Literature Series and Review of Literature
Background: Fungal infections of the central nervous system (CNS) usually present as subacute meningitis or intracranial space-occupying lesion with mass effect on surrounding structures and consequent focal neurological deficits. Intracranial fungal granulomas are often misdiagnosed clinically and...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Guilan University of Medical Sciences
2020-07-01
|
| Series: | Iranian Journal of Neurosurgery |
| Subjects: | |
| Online Access: | http://irjns.org/article-1-207-en.pdf |
| _version_ | 1797778216725774336 |
|---|---|
| author | Ashok Gandhi Surendra Jain Sapna Gandhi Keshav Mishra Sashikant Jain |
| author_facet | Ashok Gandhi Surendra Jain Sapna Gandhi Keshav Mishra Sashikant Jain |
| author_sort | Ashok Gandhi |
| collection | DOAJ |
| description | Background: Fungal infections of the central nervous system (CNS) usually present as subacute meningitis or intracranial space-occupying lesion with mass effect on surrounding structures and consequent focal neurological deficits. Intracranial fungal granulomas are often misdiagnosed clinically and radiologically as neoplastic lesions. Biopsy of the lesion is the only reliable technique to establish the correct diagnosis as well as to detect the causative fungal species. Voriconazole is a broad-spectrum triazole antifungal agent. It can be given orally and intravenously and has lesser adverse effects.
Methods and Materials: In this article, we report a series of 6 cases of biopsy-proven fungal granuloma with varied clinical and radiological presentations who were given treatment with voriconazole for 6 months and demonstrated favorable response.
Results: Out of 6 patients (4 males and 2 females), 1 was immunocompromised (DM with uncontrolled hyperglycemia). Headache was the most commonly observed symptom. Paranasal sinus and anterior cranial fossa were the most commonly affected site. Four patients received voriconazole therapy for 12 months and 1 received the same for 6 months before showing clinical resolution of disease. There was 1 death in the study group from non-related medical complications.
Conclusion: Our series focuses on the correct diagnosis of fungal granuloma which can be achieved by biopsy and clinical evidence of the efficacy of voriconazole against intracranial fungal granuloma. |
| first_indexed | 2024-03-12T23:14:05Z |
| format | Article |
| id | doaj.art-075904e76868420896a4fe88ae195a07 |
| institution | Directory Open Access Journal |
| issn | 2423-6497 2423-6829 |
| language | English |
| last_indexed | 2024-03-12T23:14:05Z |
| publishDate | 2020-07-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Neurosurgery |
| spelling | doaj.art-075904e76868420896a4fe88ae195a072023-07-17T13:29:15ZengGuilan University of Medical SciencesIranian Journal of Neurosurgery2423-64972423-68292020-07-0163143150Intracranial Mass Lesion Due to Fungal Infection: A Case Series and Review of Literature Series and Review of LiteratureAshok Gandhi0Surendra Jain1Sapna Gandhi2Keshav Mishra3Sashikant Jain4 Department of Neurosurgery, SMS Medical College, Jaipur, Rajasthan, India. Department of Neurosurgery, SMS Medical College, Jaipur, Rajasthan, India. Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India. Department of Neurosurgery, SMS Medical College, Jaipur, Rajasthan, India. Department of Neurosurgery, SMS Medical College, Jaipur, Rajasthan, India. Background: Fungal infections of the central nervous system (CNS) usually present as subacute meningitis or intracranial space-occupying lesion with mass effect on surrounding structures and consequent focal neurological deficits. Intracranial fungal granulomas are often misdiagnosed clinically and radiologically as neoplastic lesions. Biopsy of the lesion is the only reliable technique to establish the correct diagnosis as well as to detect the causative fungal species. Voriconazole is a broad-spectrum triazole antifungal agent. It can be given orally and intravenously and has lesser adverse effects. Methods and Materials: In this article, we report a series of 6 cases of biopsy-proven fungal granuloma with varied clinical and radiological presentations who were given treatment with voriconazole for 6 months and demonstrated favorable response. Results: Out of 6 patients (4 males and 2 females), 1 was immunocompromised (DM with uncontrolled hyperglycemia). Headache was the most commonly observed symptom. Paranasal sinus and anterior cranial fossa were the most commonly affected site. Four patients received voriconazole therapy for 12 months and 1 received the same for 6 months before showing clinical resolution of disease. There was 1 death in the study group from non-related medical complications. Conclusion: Our series focuses on the correct diagnosis of fungal granuloma which can be achieved by biopsy and clinical evidence of the efficacy of voriconazole against intracranial fungal granuloma.http://irjns.org/article-1-207-en.pdfvoriconazolefungal granulomabiopsy |
| spellingShingle | Ashok Gandhi Surendra Jain Sapna Gandhi Keshav Mishra Sashikant Jain Intracranial Mass Lesion Due to Fungal Infection: A Case Series and Review of Literature Series and Review of Literature Iranian Journal of Neurosurgery voriconazole fungal granuloma biopsy |
| title | Intracranial Mass Lesion Due to Fungal Infection: A Case Series and Review of Literature
Series and Review of Literature |
| title_full | Intracranial Mass Lesion Due to Fungal Infection: A Case Series and Review of Literature
Series and Review of Literature |
| title_fullStr | Intracranial Mass Lesion Due to Fungal Infection: A Case Series and Review of Literature
Series and Review of Literature |
| title_full_unstemmed | Intracranial Mass Lesion Due to Fungal Infection: A Case Series and Review of Literature
Series and Review of Literature |
| title_short | Intracranial Mass Lesion Due to Fungal Infection: A Case Series and Review of Literature
Series and Review of Literature |
| title_sort | intracranial mass lesion due to fungal infection a case series and review of literature series and review of literature |
| topic | voriconazole fungal granuloma biopsy |
| url | http://irjns.org/article-1-207-en.pdf |
| work_keys_str_mv | AT ashokgandhi intracranialmasslesionduetofungalinfectionacaseseriesandreviewofliteratureseriesandreviewofliterature AT surendrajain intracranialmasslesionduetofungalinfectionacaseseriesandreviewofliteratureseriesandreviewofliterature AT sapnagandhi intracranialmasslesionduetofungalinfectionacaseseriesandreviewofliteratureseriesandreviewofliterature AT keshavmishra intracranialmasslesionduetofungalinfectionacaseseriesandreviewofliteratureseriesandreviewofliterature AT sashikantjain intracranialmasslesionduetofungalinfectionacaseseriesandreviewofliteratureseriesandreviewofliterature |