JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia

JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia

Sequencing data from large cohorts of T-cell acute lymphoblastic leukemia patients identified a significant association between the presence of JAK3 mutations and ectopic HOXA9 expression. Mouse models using a constitutive or novel inducible retroviral expression vector to express the JAK3(M511I) mu...

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Bibliographic Details
Main Authors: Charles E. de Bock, Jan Cools
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:Molecular & Cellular Oncology
Subjects:
signaling
transcription factor
leukemia
retroviral vector
Online Access:http://dx.doi.org/10.1080/23723556.2018.1458014

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