Poly-thymidine oligonucleotides mediate activation of murine glial cells primarily through TLR7, not TLR8.

Poly-thymidine oligonucleotides mediate activation of murine glial cells primarily through TLR7, not TLR8.

The functional role of murine TLR8 in the inflammatory response of the central nervous system (CNS) remains unclear. Murine TLR8 does not appear to respond to human TLR7/8 agonists, due to a five amino acid deletion in the ectodomain. However, recent studies have suggested that murine TLR8 may be st...

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Bibliographic Details
Main Authors: Min Du, Niranjan B Butchi, Tyson Woods, Karin E Peterson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3141064?pdf=render

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