<i>Nigella sativa</i> L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature
COVID-19 has had an impact on human quality of life and economics. Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants. <i>Nigella sativa</i> L. (NS) is an important medicinal plant of Islamic value. This review highlight...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/9/2750 |
| _version_ | 1797503685336498176 |
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| author | Mohd Imran Shah Alam Khan Abida Mohammed Kanan Alshammari Saif M. Alkhaldi Fayez Nafea Alshammari Mehnaz Kamal Ozair Alam Syed Mohammed Basheeruddin Asdaq A. Khuzaim Alzahrani Shahamah Jomah |
| author_facet | Mohd Imran Shah Alam Khan Abida Mohammed Kanan Alshammari Saif M. Alkhaldi Fayez Nafea Alshammari Mehnaz Kamal Ozair Alam Syed Mohammed Basheeruddin Asdaq A. Khuzaim Alzahrani Shahamah Jomah |
| author_sort | Mohd Imran |
| collection | DOAJ |
| description | COVID-19 has had an impact on human quality of life and economics. Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants. <i>Nigella sativa</i> L. (NS) is an important medicinal plant of Islamic value. This review highlights the anti-COVID-19 potential, clinical trials, inventions, and patent literature related to NS and its major chemical constituents, like thymoquinone. The literature was collected from different databases, including Pubmed, Espacenet, and Patentscope. The literature supports the efficacy of NS, NS oil (NSO), and its chemical constituents against COVID-19. The clinical data imply that NS and NSO can prevent and treat COVID-19 patients with a faster recovery rate. Several inventions comprising NS and NSO have been claimed in patent applications to prevent/treat COVID-19. The patent literature cites NS as an immunomodulator, antioxidant, anti-inflammatory, a source of anti-SARS-CoV-2 compounds, and a plant having protective effects on the lungs. The available facts indicate that NS, NSO, and its various compositions have all the attributes to be used as a promising remedy to prevent, manage, and treat COVID-19 among high-risk people as well as for the therapy of COVID-19 patients of all age groups as a monotherapy or a combination therapy. Many compositions of NS in combination with countless medicinal herbs and medicines are still unexplored. Accordingly, the authors foresee a bright scope in developing NS-based anti-COVID-19 composition for clinical use in the future. |
| first_indexed | 2024-03-10T03:54:15Z |
| format | Article |
| id | doaj.art-075edb13891d4f88bb8a09ff9910c8a6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:54:15Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-075edb13891d4f88bb8a09ff9910c8a62023-11-23T08:49:05ZengMDPI AGMolecules1420-30492022-04-01279275010.3390/molecules27092750<i>Nigella sativa</i> L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent LiteratureMohd Imran0Shah Alam Khan1Abida2Mohammed Kanan Alshammari3Saif M. Alkhaldi4Fayez Nafea Alshammari5Mehnaz Kamal6Ozair Alam7Syed Mohammed Basheeruddin Asdaq8A. Khuzaim Alzahrani9Shahamah Jomah10Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, National University of Science and Technology, Muscat 130, OmanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi ArabiaDepartment of Pharmaceutical Care, Rafha Central Hospital, Rafha 91911, Saudi ArabiaDepartment of Pharmaceutical Care, King Khalid Hospital in Majmaah, Riyadh 76312, Saudi ArabiaCommunity Pharmacist, Al-Dawaa Pharmacies, Hafer Albatin 39911, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi ArabiaMedicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, IndiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh 13713, Saudi ArabiaDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, Arar 91431, Saudi ArabiaPharmacy Department, Sulaiman Al-Habib Medical Group, Riyadh 11643, Saudi ArabiaCOVID-19 has had an impact on human quality of life and economics. Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants. <i>Nigella sativa</i> L. (NS) is an important medicinal plant of Islamic value. This review highlights the anti-COVID-19 potential, clinical trials, inventions, and patent literature related to NS and its major chemical constituents, like thymoquinone. The literature was collected from different databases, including Pubmed, Espacenet, and Patentscope. The literature supports the efficacy of NS, NS oil (NSO), and its chemical constituents against COVID-19. The clinical data imply that NS and NSO can prevent and treat COVID-19 patients with a faster recovery rate. Several inventions comprising NS and NSO have been claimed in patent applications to prevent/treat COVID-19. The patent literature cites NS as an immunomodulator, antioxidant, anti-inflammatory, a source of anti-SARS-CoV-2 compounds, and a plant having protective effects on the lungs. The available facts indicate that NS, NSO, and its various compositions have all the attributes to be used as a promising remedy to prevent, manage, and treat COVID-19 among high-risk people as well as for the therapy of COVID-19 patients of all age groups as a monotherapy or a combination therapy. Many compositions of NS in combination with countless medicinal herbs and medicines are still unexplored. Accordingly, the authors foresee a bright scope in developing NS-based anti-COVID-19 composition for clinical use in the future.https://www.mdpi.com/1420-3049/27/9/2750<i>Nigella sativa</i> L.black seedSARS-CoV-2COVID-19clinical trialinvention |
| spellingShingle | Mohd Imran Shah Alam Khan Abida Mohammed Kanan Alshammari Saif M. Alkhaldi Fayez Nafea Alshammari Mehnaz Kamal Ozair Alam Syed Mohammed Basheeruddin Asdaq A. Khuzaim Alzahrani Shahamah Jomah <i>Nigella sativa</i> L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature Molecules <i>Nigella sativa</i> L. black seed SARS-CoV-2 COVID-19 clinical trial invention |
| title | <i>Nigella sativa</i> L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature |
| title_full | <i>Nigella sativa</i> L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature |
| title_fullStr | <i>Nigella sativa</i> L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature |
| title_full_unstemmed | <i>Nigella sativa</i> L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature |
| title_short | <i>Nigella sativa</i> L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature |
| title_sort | i nigella sativa i l and covid 19 a glance at the anti covid 19 chemical constituents clinical trials inventions and patent literature |
| topic | <i>Nigella sativa</i> L. black seed SARS-CoV-2 COVID-19 clinical trial invention |
| url | https://www.mdpi.com/1420-3049/27/9/2750 |
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