| Summary: | This paper presents a high-precision biomedical sensor system with a novel analog-frontend (AFE) IC and error correction by machine learning. The AFE IC embeds an analog-to-digital converter (ADC) architecture called successive stochastic approximation ADC. The proposed ADC integrates a stochastic flash ADC (SF-ADC) into a successive approximation register ADC (SAR-ADC) to enhance its resolution. The SF-ADC is also used as a digitally controlled variable threshold comparator to provide error correction of the SAR-ADC. The proposed system also calibrates the ADC error using the machine learning algorithm on an external PC without additional power dissipation at a sensor node. Due to the flexibility of the system, the design complexity of an AFE IC can be relaxed by using these techniques. The target resolution is 18 bits, and the target bandwidth (without digital low-pass filter) is about 5 kHz to deal with several types of biopotential signals. The design is fabricated in a 130-nm CMOS process and operates at 1.2-V supply. The fabricated ADC achieves the SNDR of 88 dB at a sampling frequency of 250 kHz by using the proposed calibration techniques. Due to the high-resolution ADC, the input-referred noise is 2.52 μV<sub>rms</sub> with a gain of 28.5 dB.
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