Dendronized Gelatin-Mediated Synthesis of Gold Nanoparticles
Thermoresponsive dendronized gelatins (<b>GelG1</b>) or gelatin methacrylates (<b>GelG1MA</b>) were used as precursors to modulate the efficient reduction of Au(III) to form stable gold nanoparticles (AuNPs) through UV irradiation. These dendronized gelatins were obtained thr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/18/6096 |
| _version_ | 1797484176101867520 |
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| author | Yan Ding Xiacong Zhang Wen Li Afang Zhang |
| author_facet | Yan Ding Xiacong Zhang Wen Li Afang Zhang |
| author_sort | Yan Ding |
| collection | DOAJ |
| description | Thermoresponsive dendronized gelatins (<b>GelG1</b>) or gelatin methacrylates (<b>GelG1MA</b>) were used as precursors to modulate the efficient reduction of Au(III) to form stable gold nanoparticles (AuNPs) through UV irradiation. These dendronized gelatins were obtained through the amidation of gelatin or gelatin methacrylates with dendritic oligoethylene glycols (OEGs). Crowded OEG dendrons along the gelatin backbones create a hydrophobic microenvironment, which promotes the reduction of Au(III). Gelatin backbones act as ligands through the electron-rich groups to facilitate the reduction, while the dendritic OEGs provide shielding effects through crowding to form a hydrophobic microenvironment, which not only enhances the reduction but also stabilize the formed AuNPs through encapsulation. The effects of dendron coverage on the dendronized biomacromolecules and their thermoresponsiveness on the reduction kinetics were examined. Dendronized gelatin/AuNPs hydrogels were further prepared through the in situ photo-crosslinking of <b>GelG1MA</b>. The modification of natural macromolecules through dendronization presented in this report facilitates a novel platform for the environmentally friendly synthesis of noble metal nanoparticles, which may form a new strategy for developing smart nano-biosensors and nano-devices. |
| first_indexed | 2024-03-09T22:59:40Z |
| format | Article |
| id | doaj.art-076100c66be64a3987d7bd22c1668518 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T22:59:40Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-076100c66be64a3987d7bd22c16685182023-11-23T18:04:19ZengMDPI AGMolecules1420-30492022-09-012718609610.3390/molecules27186096Dendronized Gelatin-Mediated Synthesis of Gold NanoparticlesYan Ding0Xiacong Zhang1Wen Li2Afang Zhang3International Joint Laboratory of Biomimetic and Smart Polymers, School of Materials Science & Engineering, Shanghai University, Shanghai 200444, ChinaInternational Joint Laboratory of Biomimetic and Smart Polymers, School of Materials Science & Engineering, Shanghai University, Shanghai 200444, ChinaInternational Joint Laboratory of Biomimetic and Smart Polymers, School of Materials Science & Engineering, Shanghai University, Shanghai 200444, ChinaInternational Joint Laboratory of Biomimetic and Smart Polymers, School of Materials Science & Engineering, Shanghai University, Shanghai 200444, ChinaThermoresponsive dendronized gelatins (<b>GelG1</b>) or gelatin methacrylates (<b>GelG1MA</b>) were used as precursors to modulate the efficient reduction of Au(III) to form stable gold nanoparticles (AuNPs) through UV irradiation. These dendronized gelatins were obtained through the amidation of gelatin or gelatin methacrylates with dendritic oligoethylene glycols (OEGs). Crowded OEG dendrons along the gelatin backbones create a hydrophobic microenvironment, which promotes the reduction of Au(III). Gelatin backbones act as ligands through the electron-rich groups to facilitate the reduction, while the dendritic OEGs provide shielding effects through crowding to form a hydrophobic microenvironment, which not only enhances the reduction but also stabilize the formed AuNPs through encapsulation. The effects of dendron coverage on the dendronized biomacromolecules and their thermoresponsiveness on the reduction kinetics were examined. Dendronized gelatin/AuNPs hydrogels were further prepared through the in situ photo-crosslinking of <b>GelG1MA</b>. The modification of natural macromolecules through dendronization presented in this report facilitates a novel platform for the environmentally friendly synthesis of noble metal nanoparticles, which may form a new strategy for developing smart nano-biosensors and nano-devices.https://www.mdpi.com/1420-3049/27/18/6096gelatingold nanoparticlesdendronized polymerthermoresponsivenessmicroconfinement |
| spellingShingle | Yan Ding Xiacong Zhang Wen Li Afang Zhang Dendronized Gelatin-Mediated Synthesis of Gold Nanoparticles Molecules gelatin gold nanoparticles dendronized polymer thermoresponsiveness microconfinement |
| title | Dendronized Gelatin-Mediated Synthesis of Gold Nanoparticles |
| title_full | Dendronized Gelatin-Mediated Synthesis of Gold Nanoparticles |
| title_fullStr | Dendronized Gelatin-Mediated Synthesis of Gold Nanoparticles |
| title_full_unstemmed | Dendronized Gelatin-Mediated Synthesis of Gold Nanoparticles |
| title_short | Dendronized Gelatin-Mediated Synthesis of Gold Nanoparticles |
| title_sort | dendronized gelatin mediated synthesis of gold nanoparticles |
| topic | gelatin gold nanoparticles dendronized polymer thermoresponsiveness microconfinement |
| url | https://www.mdpi.com/1420-3049/27/18/6096 |
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