Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress
Objectives: Aluminum phosphide (AIP) is the commonly used pesticide in agriculture, which induces oxidative stress in almost all major body systems and organs. The aim of this study was to evaluate the efficacy of nanocurcumin and curcumin on serum oxidative stress level in subacute toxicity with AI...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hamadan University of Medical Sciences
2020-12-01
|
| Series: | Avicenna Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | http://ajmb.umsha.ac.ir/PDF/ajmb-8-53.pdf |
| _version_ | 1818824074153951232 |
|---|---|
| author | Somayyeh Mohammadi Pasand Akram Ranjbar Nejat Kheiripour Hassan Ghasemi Hassan Rafieemehr |
| author_facet | Somayyeh Mohammadi Pasand Akram Ranjbar Nejat Kheiripour Hassan Ghasemi Hassan Rafieemehr |
| author_sort | Somayyeh Mohammadi Pasand |
| collection | DOAJ |
| description | Objectives: Aluminum phosphide (AIP) is the commonly used pesticide in agriculture, which induces oxidative stress in almost all major body systems and organs. The aim of this study was to evaluate the efficacy of nanocurcumin and curcumin on serum oxidative stress level in subacute toxicity with AIP.
Materials and Methods: In this study 36 male Wistar rats (220-250 g) were randomly divided into six groups. Control (C) receiving normal saline; group AIPreceiving AIP (2 mg/kg daily); group Cur receiving curcumin (100 mg/kg daily); group Nano-cur receiving nanocurcumin (100 mg/kg daily); group AIP+ Cur receiving AIP (2 mg/kg daily) and curcumin (100 mg/kg daily); and group AIP and Nano-cur receiving AIP (2 mg/kg daily) and nanocurcumin (100 mg/kg daily). Serum total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), and catalase (CAT) activity were measured.
Results: AIP administration led to a significant increase in LPO, and decreased the CAT activity, TAC, and TTG compared to the control group (P<0.05). Curcumin and nanocurcumin caused a significant decrease in the levels of LPO compared to the AIP-exposed groups (P<0.05). Moreover, in the nanocurcumin-treated groups, compared to a poisoned group, TAC and TTG increased significantly (P<0.01). There were no significant changes in CAT activity improvement.
Conclusion: Nanocurcumin and curcumin improved the AIP-induced oxidative damage. |
| first_indexed | 2024-12-18T23:50:05Z |
| format | Article |
| id | doaj.art-0761954e0cde4dc793f50187d4e43a7f |
| institution | Directory Open Access Journal |
| issn | 2345-4113 |
| language | English |
| last_indexed | 2024-12-18T23:50:05Z |
| publishDate | 2020-12-01 |
| publisher | Hamadan University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Medical Biochemistry |
| spelling | doaj.art-0761954e0cde4dc793f50187d4e43a7f2022-12-21T20:47:01ZengHamadan University of Medical SciencesAvicenna Journal of Medical Biochemistry2345-41132020-12-0182535710.34172/ajmb.2020.08Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative StressSomayyeh Mohammadi Pasand0Akram Ranjbar1Nejat Kheiripour2Hassan Ghasemi3Hassan Rafieemehr4https://orcid.org/0000-0003-3904-5671Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranMedicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IranDepartment of Clinical Biochemistry, Abadan School of Medical Sciences, Abadan, IranDepartment of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, IranObjectives: Aluminum phosphide (AIP) is the commonly used pesticide in agriculture, which induces oxidative stress in almost all major body systems and organs. The aim of this study was to evaluate the efficacy of nanocurcumin and curcumin on serum oxidative stress level in subacute toxicity with AIP. Materials and Methods: In this study 36 male Wistar rats (220-250 g) were randomly divided into six groups. Control (C) receiving normal saline; group AIPreceiving AIP (2 mg/kg daily); group Cur receiving curcumin (100 mg/kg daily); group Nano-cur receiving nanocurcumin (100 mg/kg daily); group AIP+ Cur receiving AIP (2 mg/kg daily) and curcumin (100 mg/kg daily); and group AIP and Nano-cur receiving AIP (2 mg/kg daily) and nanocurcumin (100 mg/kg daily). Serum total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), and catalase (CAT) activity were measured. Results: AIP administration led to a significant increase in LPO, and decreased the CAT activity, TAC, and TTG compared to the control group (P<0.05). Curcumin and nanocurcumin caused a significant decrease in the levels of LPO compared to the AIP-exposed groups (P<0.05). Moreover, in the nanocurcumin-treated groups, compared to a poisoned group, TAC and TTG increased significantly (P<0.01). There were no significant changes in CAT activity improvement. Conclusion: Nanocurcumin and curcumin improved the AIP-induced oxidative damage.http://ajmb.umsha.ac.ir/PDF/ajmb-8-53.pdfnanocurcumincurcuminaluminum phosphideserum |
| spellingShingle | Somayyeh Mohammadi Pasand Akram Ranjbar Nejat Kheiripour Hassan Ghasemi Hassan Rafieemehr Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress Avicenna Journal of Medical Biochemistry nanocurcumin curcumin aluminum phosphide serum |
| title | Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress |
| title_full | Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress |
| title_fullStr | Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress |
| title_full_unstemmed | Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress |
| title_short | Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress |
| title_sort | antioxidative effects of nanocurcumin and curcumin against aluminum phosphide induced serum oxidative stress |
| topic | nanocurcumin curcumin aluminum phosphide serum |
| url | http://ajmb.umsha.ac.ir/PDF/ajmb-8-53.pdf |
| work_keys_str_mv | AT somayyehmohammadipasand antioxidativeeffectsofnanocurcuminandcurcuminagainstaluminumphosphideinducedserumoxidativestress AT akramranjbar antioxidativeeffectsofnanocurcuminandcurcuminagainstaluminumphosphideinducedserumoxidativestress AT nejatkheiripour antioxidativeeffectsofnanocurcuminandcurcuminagainstaluminumphosphideinducedserumoxidativestress AT hassanghasemi antioxidativeeffectsofnanocurcuminandcurcuminagainstaluminumphosphideinducedserumoxidativestress AT hassanrafieemehr antioxidativeeffectsofnanocurcuminandcurcuminagainstaluminumphosphideinducedserumoxidativestress |