Characterization of 15 CYP2J2 variants identified in the Chinese Han population on the metabolism of ebastine and terfenadine in vitro

Characterization of 15 CYP2J2 variants identified in the Chinese Han population on the metabolism of ebastine and terfenadine in vitro

Genetic polymorphism of the cytochrome P450 (CYP) gene can significantly influence the metabolism of endogenous and xenobiotic compounds. However, few studies have focused on the polymorphism of CYP2J2 and its impact on drug catalytic activity, especially in the Chinese Han population. In this study...

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Bibliographic Details
Main Authors: Li-Li Zou, Fang-Ling Zhao, Yu-Ying Qi, Shuang-Hu Wang, Quan Zhou, Pei-Wu Geng, Yun-Fang Zhou, Qing Zhang, Hao Chen, Da-Peng Dai, Jian-Ping Cai, Fu-Sui Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
CYP2J2
polymorphism
allelic variant
catalytic activity
Chinese Han
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1186824/full

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