The relationship between self-perceived fatigue, muscle endurance, and circulating markers of inflammation in participants of the Copenhagen aging and Midlife Biobank (CAMB)
Abstract Background Fatigue, low muscle endurance, muscle weakness and low-grade inflammation are strongly related to frailty at higher age. When signs of self-perceived fatigue and low muscle endurance are interrelated with low-grade inflammation at midlife, they might be used as early markers for...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | European Review of Aging and Physical Activity |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11556-024-00336-9 |
| _version_ | 1827328236632145920 |
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| author | Ivan Bautmans Veerle Knoop Ingo Beyer Helle Bruunsgaard Drude Molbo Erik Lykke Mortensen Rikke Lund |
| author_facet | Ivan Bautmans Veerle Knoop Ingo Beyer Helle Bruunsgaard Drude Molbo Erik Lykke Mortensen Rikke Lund |
| author_sort | Ivan Bautmans |
| collection | DOAJ |
| description | Abstract Background Fatigue, low muscle endurance, muscle weakness and low-grade inflammation are strongly related to frailty at higher age. When signs of self-perceived fatigue and low muscle endurance are interrelated with low-grade inflammation at midlife, they might be used as early markers for frailty. This study investigated whether the interrelationships among self-perceived fatigue, muscle endurance and inflammation can be observed at midlife. Methods A total of 965 participants of the Copenhagen Aging and Midlife Biobank (aged 52 ± 4 years, 536 males, 426 females) were assessed for self-perceived fatigue (20-item multidimensional fatigue inventory), muscle endurance (grip work), circulating markers of inflammation (hsCRP, IL-6, IL-10, TNF-alpha and IFN-γ), daily physical activity (PAS-2), body composition (%body fat assessed by bio-impedance) and self-reported health status. Participants were categorised (correcting for age and gender) according to high fatigue and/or low muscle endurance, differences in inflammatory profile between fatigue categories were assessed by ANCOVA (corrected for PAS-2, %body fat and presence of inflammatory conditions). Results Overall, muscle endurance, fatigue and inflammatory markers were significantly interrelated. Higher levels of hsCRP (p < 0.001), IL-6 (p < 0.001), IL-10 (p = 0.035) and TNF-alpha (p = 0.028) were observed in participants presenting both low muscle endurance and high fatigue. IFN-γ was highest in those with high fatigue but normal muscle endurance (p = 0.015). Conclusions Middle-aged participants with higher fatigue in combination with low muscle endurance show higher levels of inflammation, independently from physical activity, body fat and inflammatory pathology. The underlying mechanisms should be identified and future studies should also investigate whether these individuals show early signs of reduced physiological reserve capacity, which in later life come to full expression by means of frailty. |
| first_indexed | 2024-03-07T15:14:38Z |
| format | Article |
| id | doaj.art-0762ef3c857f4517a3fb0d592b02b3fc |
| institution | Directory Open Access Journal |
| issn | 1861-6909 |
| language | English |
| last_indexed | 2024-03-07T15:14:38Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | European Review of Aging and Physical Activity |
| spelling | doaj.art-0762ef3c857f4517a3fb0d592b02b3fc2024-03-05T17:58:39ZengBMCEuropean Review of Aging and Physical Activity1861-69092024-01-0121111410.1186/s11556-024-00336-9The relationship between self-perceived fatigue, muscle endurance, and circulating markers of inflammation in participants of the Copenhagen aging and Midlife Biobank (CAMB)Ivan Bautmans0Veerle Knoop1Ingo Beyer2Helle Bruunsgaard3Drude Molbo4Erik Lykke Mortensen5Rikke Lund6Gerontology department (GERO), Vrije Universiteit BrusselGerontology department (GERO), Vrije Universiteit BrusselGerontology department (GERO), Vrije Universiteit BrusselCenter for Healthy Aging, University of CopenhagenSection of Environmental Health, Department of Public Health, University of CopenhagenSection of Social Medicine, Department of Public Health, University of CopenhagenSection of Social Medicine, Department of Public Health, University of CopenhagenAbstract Background Fatigue, low muscle endurance, muscle weakness and low-grade inflammation are strongly related to frailty at higher age. When signs of self-perceived fatigue and low muscle endurance are interrelated with low-grade inflammation at midlife, they might be used as early markers for frailty. This study investigated whether the interrelationships among self-perceived fatigue, muscle endurance and inflammation can be observed at midlife. Methods A total of 965 participants of the Copenhagen Aging and Midlife Biobank (aged 52 ± 4 years, 536 males, 426 females) were assessed for self-perceived fatigue (20-item multidimensional fatigue inventory), muscle endurance (grip work), circulating markers of inflammation (hsCRP, IL-6, IL-10, TNF-alpha and IFN-γ), daily physical activity (PAS-2), body composition (%body fat assessed by bio-impedance) and self-reported health status. Participants were categorised (correcting for age and gender) according to high fatigue and/or low muscle endurance, differences in inflammatory profile between fatigue categories were assessed by ANCOVA (corrected for PAS-2, %body fat and presence of inflammatory conditions). Results Overall, muscle endurance, fatigue and inflammatory markers were significantly interrelated. Higher levels of hsCRP (p < 0.001), IL-6 (p < 0.001), IL-10 (p = 0.035) and TNF-alpha (p = 0.028) were observed in participants presenting both low muscle endurance and high fatigue. IFN-γ was highest in those with high fatigue but normal muscle endurance (p = 0.015). Conclusions Middle-aged participants with higher fatigue in combination with low muscle endurance show higher levels of inflammation, independently from physical activity, body fat and inflammatory pathology. The underlying mechanisms should be identified and future studies should also investigate whether these individuals show early signs of reduced physiological reserve capacity, which in later life come to full expression by means of frailty.https://doi.org/10.1186/s11556-024-00336-9FrailtyMuscle fatigueAgeingHandgrip strengthGrip work |
| spellingShingle | Ivan Bautmans Veerle Knoop Ingo Beyer Helle Bruunsgaard Drude Molbo Erik Lykke Mortensen Rikke Lund The relationship between self-perceived fatigue, muscle endurance, and circulating markers of inflammation in participants of the Copenhagen aging and Midlife Biobank (CAMB) European Review of Aging and Physical Activity Frailty Muscle fatigue Ageing Handgrip strength Grip work |
| title | The relationship between self-perceived fatigue, muscle endurance, and circulating markers of inflammation in participants of the Copenhagen aging and Midlife Biobank (CAMB) |
| title_full | The relationship between self-perceived fatigue, muscle endurance, and circulating markers of inflammation in participants of the Copenhagen aging and Midlife Biobank (CAMB) |
| title_fullStr | The relationship between self-perceived fatigue, muscle endurance, and circulating markers of inflammation in participants of the Copenhagen aging and Midlife Biobank (CAMB) |
| title_full_unstemmed | The relationship between self-perceived fatigue, muscle endurance, and circulating markers of inflammation in participants of the Copenhagen aging and Midlife Biobank (CAMB) |
| title_short | The relationship between self-perceived fatigue, muscle endurance, and circulating markers of inflammation in participants of the Copenhagen aging and Midlife Biobank (CAMB) |
| title_sort | relationship between self perceived fatigue muscle endurance and circulating markers of inflammation in participants of the copenhagen aging and midlife biobank camb |
| topic | Frailty Muscle fatigue Ageing Handgrip strength Grip work |
| url | https://doi.org/10.1186/s11556-024-00336-9 |
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