Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?
Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism. They have received extensive attention in bridging the gap between environmental exposures and disease development via their influence...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2021-05-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304220300118 |
| _version_ | 1827267385557516288 |
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| author | S. Mohana Devi I. Mahalaxmi J. Kaavya V. Chinnkulandhai V. Balachandar |
| author_facet | S. Mohana Devi I. Mahalaxmi J. Kaavya V. Chinnkulandhai V. Balachandar |
| author_sort | S. Mohana Devi |
| collection | DOAJ |
| description | Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism. They have received extensive attention in bridging the gap between environmental exposures and disease development via their influence on gene expression. DNA methylation is the earliest discovered epigenetic alteration. In this review, we try to examine the role of DNA methylation and histone modification in Age related macular degeneration (AMD) and Diabetic Retinopathy (DR), its vascular complications and recent progress. Given the complex nature of AMD and DR, it is crucial to improve therapeutics which will greatly enhance the quality of life and reduce the burden for millions of patients living with these potentially blinding conditions. |
| first_indexed | 2024-03-12T08:29:25Z |
| format | Article |
| id | doaj.art-0763b5363bba49dabddbd3d527843ff6 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2025-03-22T04:32:54Z |
| publishDate | 2021-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-0763b5363bba49dabddbd3d527843ff62024-04-28T02:30:54ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422021-05-0183279286Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?S. Mohana Devi0I. Mahalaxmi1J. Kaavya2V. Chinnkulandhai3V. Balachandar4SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, 41/18, College Road, Chennai, 600006, IndiaDepartment of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Avinashilingam University for Women, Coimbatore, Tamil Nadu, 641046, IndiaDepartment of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Avinashilingam University for Women, Coimbatore, Tamil Nadu, 641046, IndiaDepartment of Biochemistry, Dr.N.G.P Arts and Science College, Coimbatore, Tamil Nadu, 641046, IndiaHuman Molecular Genetics and Stem Cells Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, 641046, India; Corresponding author. Human Molecular Cytogenetics & Stem Cell Lab, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, 641 046, Tamil Nadu, India. Fax: +91 422 2422387.Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism. They have received extensive attention in bridging the gap between environmental exposures and disease development via their influence on gene expression. DNA methylation is the earliest discovered epigenetic alteration. In this review, we try to examine the role of DNA methylation and histone modification in Age related macular degeneration (AMD) and Diabetic Retinopathy (DR), its vascular complications and recent progress. Given the complex nature of AMD and DR, it is crucial to improve therapeutics which will greatly enhance the quality of life and reduce the burden for millions of patients living with these potentially blinding conditions.http://www.sciencedirect.com/science/article/pii/S2352304220300118Age-related macular degeneration (AMD)Diabetic Retinopathy (DR)EpigeneticsGene expression |
| spellingShingle | S. Mohana Devi I. Mahalaxmi J. Kaavya V. Chinnkulandhai V. Balachandar Does epigenetics have a role in age related macular degeneration and diabetic retinopathy? Genes and Diseases Age-related macular degeneration (AMD) Diabetic Retinopathy (DR) Epigenetics Gene expression |
| title | Does epigenetics have a role in age related macular degeneration and diabetic retinopathy? |
| title_full | Does epigenetics have a role in age related macular degeneration and diabetic retinopathy? |
| title_fullStr | Does epigenetics have a role in age related macular degeneration and diabetic retinopathy? |
| title_full_unstemmed | Does epigenetics have a role in age related macular degeneration and diabetic retinopathy? |
| title_short | Does epigenetics have a role in age related macular degeneration and diabetic retinopathy? |
| title_sort | does epigenetics have a role in age related macular degeneration and diabetic retinopathy |
| topic | Age-related macular degeneration (AMD) Diabetic Retinopathy (DR) Epigenetics Gene expression |
| url | http://www.sciencedirect.com/science/article/pii/S2352304220300118 |
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