Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy

Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy

Abstract Hepatic encephalopathy is a neuropsychiatric complication of liver disease which is partly associated with elevated ammonemia. Urea hydrolysis by urease-producing bacteria in the colon is often mentioned as one of the main routes of ammonia production in the body, yet research on treatments...

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Bibliographic Details
Main Authors: Diana Evstafeva, Filip Ilievski, Yinyin Bao, Zhi Luo, Boris Abramovic, Sunghyun Kang, Christian Steuer, Elita Montanari, Tommaso Casalini, Dunja Simicic, Dario Sessa, Stefanita-Octavian Mitrea, Katarzyna Pierzchala, Cristina Cudalbu, Chelsie E. Armbruster, Jean-Christophe Leroux
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46481-8

Internet

https://doi.org/10.1038/s41467-024-46481-8

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