Smoking and hypertension: Effect of adenosine deaminase polymorphism
Adenosine modulates cardiovascular functions reducing blood pressure and heart rate. Adenosine deaminase (ADA) by the irreversible deamination of adenosine to inosine contributes to the regulation of adenosine concentration in body fluids. We have studied the interaction between smoking and ADA gene...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-08-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2018.1516776 |
| _version_ | 1797681349315788800 |
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| author | Fulvia Gloria-Bottini M. Banci A. Neri A. Magrini E. Bottini |
| author_facet | Fulvia Gloria-Bottini M. Banci A. Neri A. Magrini E. Bottini |
| author_sort | Fulvia Gloria-Bottini |
| collection | DOAJ |
| description | Adenosine modulates cardiovascular functions reducing blood pressure and heart rate. Adenosine deaminase (ADA) by the irreversible deamination of adenosine to inosine contributes to the regulation of adenosine concentration in body fluids. We have studied the interaction between smoking and ADA genetic variability concerning their effects on blood pressure. We have studied 344 subjects admitted to the hospital for cardiovascular diseases. The genotypes of two polymorphic loci within the ADA gene were determined: ADA1 and ADA2. Both loci show two alleles: ADA1*1 and ADA1*2 in ADA1 locus and ADA2*1 and ADA2*2 in ADA2 locus. In the absence of smoking, the proportion of subjects with hypertension tends to be lower in carriers of the ADA1*2 allele. In smoking subjects, the pattern is reversed and the proportion of those with hypertension tends to be higher in carriers of the ADA1*2 allele. A similar pattern is observed for ADA2 locus. Smoking increases the proportion of subjects showing hypertension: such effect is more marked in those carrying the ADA1*2 allele as compared to subjects with ADA1*1/*1 genotype. The same pattern of association is observed for ADA2 locus. The two loci show an additive effect. The odds ratio for hypertension in smokers vs nonsmokers is 1.450 in subjects carrying ADA1*1/*1 and ADA2*1/*1 genotypes, while it is 11.200 in subjects carrying the *2 alleles in both loci. From a practical point, a view of our results suggest that smokers carrying both ADA1*2 and ADA2*2 alleles have a higher risk of hypertension. |
| first_indexed | 2024-03-11T23:43:35Z |
| format | Article |
| id | doaj.art-0764a7a8e08c44369739eeaa3c468390 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:35Z |
| publishDate | 2019-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-0764a7a8e08c44369739eeaa3c4683902023-09-19T15:19:27ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062019-08-0141654855110.1080/10641963.2018.15167761516776Smoking and hypertension: Effect of adenosine deaminase polymorphismFulvia Gloria-Bottini0M. Banci1A. Neri2A. Magrini3E. Bottini4University of Tor VergataValmontone Hospital, ValmontoneUniversity of Tor VergataUniversity of Tor VergataUniversity of Tor VergataAdenosine modulates cardiovascular functions reducing blood pressure and heart rate. Adenosine deaminase (ADA) by the irreversible deamination of adenosine to inosine contributes to the regulation of adenosine concentration in body fluids. We have studied the interaction between smoking and ADA genetic variability concerning their effects on blood pressure. We have studied 344 subjects admitted to the hospital for cardiovascular diseases. The genotypes of two polymorphic loci within the ADA gene were determined: ADA1 and ADA2. Both loci show two alleles: ADA1*1 and ADA1*2 in ADA1 locus and ADA2*1 and ADA2*2 in ADA2 locus. In the absence of smoking, the proportion of subjects with hypertension tends to be lower in carriers of the ADA1*2 allele. In smoking subjects, the pattern is reversed and the proportion of those with hypertension tends to be higher in carriers of the ADA1*2 allele. A similar pattern is observed for ADA2 locus. Smoking increases the proportion of subjects showing hypertension: such effect is more marked in those carrying the ADA1*2 allele as compared to subjects with ADA1*1/*1 genotype. The same pattern of association is observed for ADA2 locus. The two loci show an additive effect. The odds ratio for hypertension in smokers vs nonsmokers is 1.450 in subjects carrying ADA1*1/*1 and ADA2*1/*1 genotypes, while it is 11.200 in subjects carrying the *2 alleles in both loci. From a practical point, a view of our results suggest that smokers carrying both ADA1*2 and ADA2*2 alleles have a higher risk of hypertension.http://dx.doi.org/10.1080/10641963.2018.1516776ada locus 1ada locus 2hypertensionsmokinggenetic interaction |
| spellingShingle | Fulvia Gloria-Bottini M. Banci A. Neri A. Magrini E. Bottini Smoking and hypertension: Effect of adenosine deaminase polymorphism Clinical and Experimental Hypertension ada locus 1 ada locus 2 hypertension smoking genetic interaction |
| title | Smoking and hypertension: Effect of adenosine deaminase polymorphism |
| title_full | Smoking and hypertension: Effect of adenosine deaminase polymorphism |
| title_fullStr | Smoking and hypertension: Effect of adenosine deaminase polymorphism |
| title_full_unstemmed | Smoking and hypertension: Effect of adenosine deaminase polymorphism |
| title_short | Smoking and hypertension: Effect of adenosine deaminase polymorphism |
| title_sort | smoking and hypertension effect of adenosine deaminase polymorphism |
| topic | ada locus 1 ada locus 2 hypertension smoking genetic interaction |
| url | http://dx.doi.org/10.1080/10641963.2018.1516776 |
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