Anodal transcranial direct current stimulation of parietal cortex enhances action naming in Corticobasal Syndrome
Background: Corticobasal Syndrome (CBS) is a neurodegenerative disorder that overlaps both clinically and neuropathologically with Frontotemporal dementia and is characterized by apraxia, alien limb phenomena, cortical sensory loss, cognitive impairment, behavioural changes and aphasia. It has been...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00049/full |
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| author | Rosa eManenti Marta eBianchi Maura eCosseddu Michela eBrambilla Cristina eRizzetti Alessandro ePadovani Barbara eBorroni Maria eCotelli |
| author_facet | Rosa eManenti Marta eBianchi Maura eCosseddu Michela eBrambilla Cristina eRizzetti Alessandro ePadovani Barbara eBorroni Maria eCotelli |
| author_sort | Rosa eManenti |
| collection | DOAJ |
| description | Background: Corticobasal Syndrome (CBS) is a neurodegenerative disorder that overlaps both clinically and neuropathologically with Frontotemporal dementia and is characterized by apraxia, alien limb phenomena, cortical sensory loss, cognitive impairment, behavioural changes and aphasia. It has been recently demonstrated that transcranial direct current stimulation (tDCS) improves naming in healthy subjects and in subjects with language deficits.Objective: The aim of the present study was to explore the extent to which anodal transcranial direct current stimulation (anodal tDCS) over the parietal cortex (PARC) could facilitate naming performance in CBS subjects. Methods: Anodal tDCS was applied to the left and right PARC during object and action naming in seventeen patients with a diagnosis of possible CBS. Participants underwent two sessions of anodal tDCS (left and right) and one session of placebo tDCS. Vocal responses were recorded and analyzed for accuracy and vocal Reaction Times (vRTs). Results: A shortening of naming latency for actions was observed only after active anodal stimulation over the left PARC, as compared to placebo and right stimulations. No effects have been reported for accuracy.Conclusions: Our preliminary finding demonstrated that tDCS decreased vocal reaction time during action naming in a sample of patients with CBS. A possible explanation of our results is that anodal tDCS over the left PARC effects the brain network implicated in action observation and representation. Further studies, based on larger patient samples, should be conducted to investigate the usefulness of tDCS as an additional treatment of linguistic deficits in CBS patients. |
| first_indexed | 2024-12-16T16:08:55Z |
| format | Article |
| id | doaj.art-0765e7da0ead4cbe87ff94e18357d6a6 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-16T16:08:55Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-0765e7da0ead4cbe87ff94e18357d6a62022-12-21T22:25:17ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-04-01710.3389/fnagi.2015.00049138588Anodal transcranial direct current stimulation of parietal cortex enhances action naming in Corticobasal SyndromeRosa eManenti0Marta eBianchi1Maura eCosseddu2Michela eBrambilla3Cristina eRizzetti4Alessandro ePadovani5Barbara eBorroni6Maria eCotelli7Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio - FatebenefratelliCentre for Aging Brain and Neurodegenerative Disorders, Neurology unit, University of BresciaCentre for Aging Brain and Neurodegenerative Disorders, Neurology unit, University of BresciaNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio - FatebenefratelliS. Isidoro HospitalCentre for Aging Brain and Neurodegenerative Disorders, Neurology unit, University of BresciaCentre for Aging Brain and Neurodegenerative Disorders, Neurology unit, University of BresciaNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio - FatebenefratelliBackground: Corticobasal Syndrome (CBS) is a neurodegenerative disorder that overlaps both clinically and neuropathologically with Frontotemporal dementia and is characterized by apraxia, alien limb phenomena, cortical sensory loss, cognitive impairment, behavioural changes and aphasia. It has been recently demonstrated that transcranial direct current stimulation (tDCS) improves naming in healthy subjects and in subjects with language deficits.Objective: The aim of the present study was to explore the extent to which anodal transcranial direct current stimulation (anodal tDCS) over the parietal cortex (PARC) could facilitate naming performance in CBS subjects. Methods: Anodal tDCS was applied to the left and right PARC during object and action naming in seventeen patients with a diagnosis of possible CBS. Participants underwent two sessions of anodal tDCS (left and right) and one session of placebo tDCS. Vocal responses were recorded and analyzed for accuracy and vocal Reaction Times (vRTs). Results: A shortening of naming latency for actions was observed only after active anodal stimulation over the left PARC, as compared to placebo and right stimulations. No effects have been reported for accuracy.Conclusions: Our preliminary finding demonstrated that tDCS decreased vocal reaction time during action naming in a sample of patients with CBS. A possible explanation of our results is that anodal tDCS over the left PARC effects the brain network implicated in action observation and representation. Further studies, based on larger patient samples, should be conducted to investigate the usefulness of tDCS as an additional treatment of linguistic deficits in CBS patients.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00049/fullDementiaLanguage Disordersparietal cortexCognitive Disordersnon invasive brain stimulationFrontotemporal dementia (FTD) |
| spellingShingle | Rosa eManenti Marta eBianchi Maura eCosseddu Michela eBrambilla Cristina eRizzetti Alessandro ePadovani Barbara eBorroni Maria eCotelli Anodal transcranial direct current stimulation of parietal cortex enhances action naming in Corticobasal Syndrome Frontiers in Aging Neuroscience Dementia Language Disorders parietal cortex Cognitive Disorders non invasive brain stimulation Frontotemporal dementia (FTD) |
| title | Anodal transcranial direct current stimulation of parietal cortex enhances action naming in Corticobasal Syndrome |
| title_full | Anodal transcranial direct current stimulation of parietal cortex enhances action naming in Corticobasal Syndrome |
| title_fullStr | Anodal transcranial direct current stimulation of parietal cortex enhances action naming in Corticobasal Syndrome |
| title_full_unstemmed | Anodal transcranial direct current stimulation of parietal cortex enhances action naming in Corticobasal Syndrome |
| title_short | Anodal transcranial direct current stimulation of parietal cortex enhances action naming in Corticobasal Syndrome |
| title_sort | anodal transcranial direct current stimulation of parietal cortex enhances action naming in corticobasal syndrome |
| topic | Dementia Language Disorders parietal cortex Cognitive Disorders non invasive brain stimulation Frontotemporal dementia (FTD) |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00049/full |
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