Prospective evaluation of improving fluoroquinolone exposure using centralised therapeutic drug monitoring (TDM) in patients with tuberculosis (PERFECT): a study protocol of a prospective multicentre cohort study

Prospective evaluation of improving fluoroquinolone exposure using centralised therapeutic drug monitoring (TDM) in patients with tuberculosis (PERFECT): a study protocol of a prospective multicentre cohort study

Introduction Global multidrug-resistant tuberculosis (MDR-TB) treatment success rates remain suboptimal. Highly active WHO group A drugs moxifloxacin and levofloxacin show intraindividual and interindividual pharmacokinetic variability which can cause low drug exposure. Therefore, therapeutic drug m...

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Bibliographic Details
Main Authors: Daan J Touw, Geoffrey Eather, Tjip S van der Werf, Giovanni Sotgiu, Simone HJ van den Elsen, Marieke GG Sturkenboom, Onno Akkerman, Linda Barkane, Judith Bruchfeld, Scott K Heysell, Henadz Hurevich, Liga Kuksa, Johanna Kuhlin, Katerina Manika, Charalampos Moschos, Stellah G Mpagama, Marcela Muñoz Torrico, Alena Skrahina, Marina Tadolini, Francesca Volpato, Malcolm R Wilson, Joaquin Zúñiga, Giovanni B Migliori, Jan-Willem Alffenaar
Format: Article
Language:English
Published: BMJ Publishing Group 2020-06-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/10/6/e035350.full

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