Age-Specific Reference Intervals for Routine Laboratory Biochemical Tests in The Iranian Adolescent Girls

Age-Specific Reference Intervals for Routine Laboratory Biochemical Tests in The Iranian Adolescent Girls

Introduction: For interpretation of the most common biochemical markers reference intervals (RIs) are widely considered and reported. Therefore, in this study, we aimed to determine age-specific RIs for some biochemical tests by removing and/or limiting critical gaps including sex, age group, geogra...

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Bibliographic Details
Main Authors: Mehran Pashirzad, Hamideh Ghazizadeh, Mohsen Seddigh Shamsi, Mahdiyeh Yaghooti-Khorasani, Reza Assaran Darban, Atieh Kamel Khodabandeh, Ensieh Akbarpour Bahre, Maryam Mohammadi Bajgiran, Amin Mansouri, Reza Javid Dash Bayyaz, Parisa Asadian, Khashayar Khanizadeh, Hale Akhtari, Melika Hadizadeh, Arvin Babaei, Sayyed Saeid Khayatzadeh, Gordon A. Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2022-12-01
Series:Journal of Cardio-Thoracic Medicine
Subjects:
adolescent girls
biochemical markers
clsi guidelines
reference intervals
Online Access:https://jctm.mums.ac.ir/article_21216_12830e94d978fb257aa9236a76035296.pdf
Description
Summary:Introduction: For interpretation of the most common biochemical markers reference intervals (RIs) are widely considered and reported. Therefore, in this study, we aimed to determine age-specific RIs for some biochemical tests by removing and/or limiting critical gaps including sex, age group, geographical region, measurement device, and type of kits and reagents for routine laboratory biochemical variables in healthy adolescent girls aged 12-19 years.Materials and Methods:  In this cross-sectional study a total of 1026 adolescent girl was recruited. According to the study aim, the levels of serum for some routine biochemical tests were measured on a BT-3000 auto-analyzer. On the basis of the non-parametric rank method and by use of CLSI Ep28-A3 guidelines, we determined age-specific RIs, including confidence interval 90%, under specific exclusion criteria.Results: Age partitioning was required for none of the upper and lower limits of biochemical markers. All Serum biochemical tests concentration remained relatively constant throughout the age range. Conclusion: By removing and/or limiting critical gaps involved in reference values of biochemical tests, it has provided an important understanding of metabolic processes and it has facilitated clinical application to track different diseases better
ISSN:2345-2447
2322-5750

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