Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice

Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice

Androgens have been known to inhibit cutaneous wound healing in men and male mice. However, in children with major burn injuries, a synthetic androgen was reported clinically to improve wound healing. The aim of this study is to investigate the role of dihydrotestosterone (DHT) as a new therapeutic...

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Bibliographic Details
Main Authors: Huaikai Shi, Tsun-Ho Lo, Duncan Ma, Brenton Condor, Brian Lesmana, Roxanne J Parungao, Kevin H.-Y. Tsai, Sarah Kim, Hsiao-Ting Chen, Pablo A Silveira, Zhe Li, Mark S Cooper, Ulla Simanainen, David J Handelsman, Peter K Maitz, Yiwei Wang
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
major burn injury
androgens
dihydrotestosterone
wound healing
inflammation
mouse model
Online Access:https://www.mdpi.com/1422-0067/21/17/6231

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