Targeting Epigenetic Mechanisms: A Boon for Cancer Immunotherapy
Immunotherapy is rapidly emerging as a promising approach against cancer. In the last decade, various immunological mechanisms have been targeted to induce an increase in the immune response against cancer cells. However, despite promising results, many patients show partial response, resistance, or...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/1/169 |
| _version_ | 1797445578692493312 |
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| author | Asmita Parab Lokesh Kumar Bhatt Abdelwahab Omri |
| author_facet | Asmita Parab Lokesh Kumar Bhatt Abdelwahab Omri |
| author_sort | Asmita Parab |
| collection | DOAJ |
| description | Immunotherapy is rapidly emerging as a promising approach against cancer. In the last decade, various immunological mechanisms have been targeted to induce an increase in the immune response against cancer cells. However, despite promising results, many patients show partial response, resistance, or serious toxicities. A promising way to overcome this is the use of immunotherapeutic approaches, in combination with other potential therapeutic approaches. Aberrant epigenetic modifications play an important role in carcinogenesis and its progression, as well as in the functioning of immune cells. Thus, therapeutic approaches targeting aberrant epigenetic mechanisms and the immune response might provide an effective antitumor effect. Further, the recent development of potent epigenetic drugs and immunomodulators gives hope to this combinatorial approach. In this review, we summarize the synergy mechanism between epigenetic therapies and immunotherapy for the treatment of cancer, and discuss recent advancements in the translation of this approach. |
| first_indexed | 2024-03-09T13:28:51Z |
| format | Article |
| id | doaj.art-0768fc8adc1544fba7b851a518c4ef43 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:28:51Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-0768fc8adc1544fba7b851a518c4ef432023-11-30T21:20:28ZengMDPI AGBiomedicines2227-90592023-01-0111116910.3390/biomedicines11010169Targeting Epigenetic Mechanisms: A Boon for Cancer ImmunotherapyAsmita Parab0Lokesh Kumar Bhatt1Abdelwahab Omri2Department of Pharmacology, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai 400 056, IndiaDepartment of Pharmacology, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai 400 056, IndiaThe Novel Drug & Vaccine Delivery Systems Facility, Department of Chemistry and Biochemistry, Laurentian University, Sudbury, ON P3E2C6, CanadaImmunotherapy is rapidly emerging as a promising approach against cancer. In the last decade, various immunological mechanisms have been targeted to induce an increase in the immune response against cancer cells. However, despite promising results, many patients show partial response, resistance, or serious toxicities. A promising way to overcome this is the use of immunotherapeutic approaches, in combination with other potential therapeutic approaches. Aberrant epigenetic modifications play an important role in carcinogenesis and its progression, as well as in the functioning of immune cells. Thus, therapeutic approaches targeting aberrant epigenetic mechanisms and the immune response might provide an effective antitumor effect. Further, the recent development of potent epigenetic drugs and immunomodulators gives hope to this combinatorial approach. In this review, we summarize the synergy mechanism between epigenetic therapies and immunotherapy for the treatment of cancer, and discuss recent advancements in the translation of this approach.https://www.mdpi.com/2227-9059/11/1/169cancer immunotherapyepigenetic regulationtumor microenvironment |
| spellingShingle | Asmita Parab Lokesh Kumar Bhatt Abdelwahab Omri Targeting Epigenetic Mechanisms: A Boon for Cancer Immunotherapy Biomedicines cancer immunotherapy epigenetic regulation tumor microenvironment |
| title | Targeting Epigenetic Mechanisms: A Boon for Cancer Immunotherapy |
| title_full | Targeting Epigenetic Mechanisms: A Boon for Cancer Immunotherapy |
| title_fullStr | Targeting Epigenetic Mechanisms: A Boon for Cancer Immunotherapy |
| title_full_unstemmed | Targeting Epigenetic Mechanisms: A Boon for Cancer Immunotherapy |
| title_short | Targeting Epigenetic Mechanisms: A Boon for Cancer Immunotherapy |
| title_sort | targeting epigenetic mechanisms a boon for cancer immunotherapy |
| topic | cancer immunotherapy epigenetic regulation tumor microenvironment |
| url | https://www.mdpi.com/2227-9059/11/1/169 |
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