R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes.

R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes.

HIV-1 is a pathogen that T cell responses fail to control. HIV-1gp120 is the surface viral envelope glycoprotein that interacts with CD4 T cells and mediates entry. HIV-1gp120 has been implicated in immune dysregulatory functions that may limit anti-HIV antigen-specific T cell responses. We hypothes...

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Bibliographic Details
Main Authors: Michael Santosuosso, Elda Righi, E David Hill, Pierre R Leblanc, Brett Kodish, Hari N Mylvaganam, Nagadenahalli B Siddappa, Liljana Stevceva, Shiu-Lok Hu, Musie Ghebremichael, Agnes-L Chenine, Avi-Hai Hovav, Ruth M Ruprecht, Mark C Poznansky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3071731?pdf=render

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