The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs

The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs

The pyrazolyl-urea Gege3 molecule has shown interesting antiangiogenic effects in the tumor contest. Here, we have studied the role of this compound as interfering with endothelial cells activation in response to the paracrine effects of annexin A1 (ANXA1), known to be involved in promoting tumor pr...

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Bibliographic Details
Main Authors: Raffaella Belvedere, Elva Morretta, Nunzia Novizio, Silvana Morello, Olga Bruno, Chiara Brullo, Antonello Petrella
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biomolecules
Subjects:
Gege3
annexin A1
extracellular vesicles
angiogenesis
PKCα inhibition
calcium mobilization
Online Access:https://www.mdpi.com/2218-273X/11/12/1758

Internet

https://www.mdpi.com/2218-273X/11/12/1758

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