Regulation of lipid droplet (LD) formation in hepatocytes via regulation of SREBP1c by non-coding RNAs

Regulation of lipid droplet (LD) formation in hepatocytes via regulation of SREBP1c by non-coding RNAs

IntroductionIncreased de novo lipogenesis (DNL) is one of the key factors contributing to fat accumulation and non-alcoholic fatty liver disease (NAFLD). Among the critical transcription factors (TFs) regulating DNL is mTOR and its downstream lipogenic TF, SREBP1c. In recent years, it has been estab...

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Bibliographic Details
Main Authors: Shereen A. El Sobky, Nourhan K. Aboud, Nihal M. El Assaly, Injie O. Fawzy, Nada El-Ekiaby, Ahmed I. Abdelaziz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Medicine
Subjects:
SREBP1c
mTOR
ncRNAs
NAFLD
de novo lipogenesis (DNL)
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.903856/full

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