Exploring the function of protein kinases in schistosomes: perspectives from the laboratory and from comparative genomics
Eukaryotic protein kinases are well conserved through evolution. The genome of Schistosoma mansoni, which causes intestinal schistosomiasis, encodes over 250 putative protein kinases with all of the main eukaryotic groups represented. However, unraveling functional roles for these kinases is a consi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00229/full |
| _version_ | 1818060629142929408 |
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| author | Anthony John Walker Margarida eRessurreição Rolf eRothermel |
| author_facet | Anthony John Walker Margarida eRessurreição Rolf eRothermel |
| author_sort | Anthony John Walker |
| collection | DOAJ |
| description | Eukaryotic protein kinases are well conserved through evolution. The genome of Schistosoma mansoni, which causes intestinal schistosomiasis, encodes over 250 putative protein kinases with all of the main eukaryotic groups represented. However, unraveling functional roles for these kinases is a considerable endeavour, particularly as protein kinases regulate multiple and sometimes overlapping cell and tissue functions in organisms. In this article, elucidating protein kinase signal transduction and function in schistosomes is considered from the perspective of the state-of-the-art methodologies used and comparative organismal biology, with a focus on current advances and future directions. Using the free-living nematode Caenorhabditis elegans as a comparator we predict roles for various schistosome protein kinases in processes vital for host invasion and successful parasitism such as sensory behaviour, growth and development. It is anticipated that the characterization of schistosome protein kinases in the context of parasite function will catalyze cutting edge research into host-parasite interactions and will reveal new targets for developing drug interventions against human schistosomiasis. |
| first_indexed | 2024-12-10T13:35:27Z |
| format | Article |
| id | doaj.art-076d7f67cbc148edae2e5c1c22f17386 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-10T13:35:27Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-076d7f67cbc148edae2e5c1c22f173862022-12-22T01:46:49ZengFrontiers Media S.A.Frontiers in Genetics1664-80212014-07-01510.3389/fgene.2014.0022986451Exploring the function of protein kinases in schistosomes: perspectives from the laboratory and from comparative genomicsAnthony John Walker0Margarida eRessurreição1Rolf eRothermel2Kingston UniversityKingston UniversityKingston UniversityEukaryotic protein kinases are well conserved through evolution. The genome of Schistosoma mansoni, which causes intestinal schistosomiasis, encodes over 250 putative protein kinases with all of the main eukaryotic groups represented. However, unraveling functional roles for these kinases is a considerable endeavour, particularly as protein kinases regulate multiple and sometimes overlapping cell and tissue functions in organisms. In this article, elucidating protein kinase signal transduction and function in schistosomes is considered from the perspective of the state-of-the-art methodologies used and comparative organismal biology, with a focus on current advances and future directions. Using the free-living nematode Caenorhabditis elegans as a comparator we predict roles for various schistosome protein kinases in processes vital for host invasion and successful parasitism such as sensory behaviour, growth and development. It is anticipated that the characterization of schistosome protein kinases in the context of parasite function will catalyze cutting edge research into host-parasite interactions and will reveal new targets for developing drug interventions against human schistosomiasis.http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00229/fullCaenorhabditis eleganscell signalling: Schistosomakinomekinase functionschistosomiasis. |
| spellingShingle | Anthony John Walker Margarida eRessurreição Rolf eRothermel Exploring the function of protein kinases in schistosomes: perspectives from the laboratory and from comparative genomics Frontiers in Genetics Caenorhabditis elegans cell signalling : Schistosoma kinome kinase function schistosomiasis. |
| title | Exploring the function of protein kinases in schistosomes: perspectives from the laboratory and from comparative genomics |
| title_full | Exploring the function of protein kinases in schistosomes: perspectives from the laboratory and from comparative genomics |
| title_fullStr | Exploring the function of protein kinases in schistosomes: perspectives from the laboratory and from comparative genomics |
| title_full_unstemmed | Exploring the function of protein kinases in schistosomes: perspectives from the laboratory and from comparative genomics |
| title_short | Exploring the function of protein kinases in schistosomes: perspectives from the laboratory and from comparative genomics |
| title_sort | exploring the function of protein kinases in schistosomes perspectives from the laboratory and from comparative genomics |
| topic | Caenorhabditis elegans cell signalling : Schistosoma kinome kinase function schistosomiasis. |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00229/full |
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