Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection
Strong adherence to a Mediterranean diet is associated with improved cognitive function and a lower prevalence of mild cognitive impairment. Olive oil and red wine are rich sources of polyphenols which are responsible in part for the beneficial effects on cognitive functioning. Polyphenols induce en...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-09-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/6/4/73 |
| _version_ | 1797701710279344128 |
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| author | Miriam Martínez-Huélamo Jose Rodríguez-Morató Anna Boronat Rafael de la Torre |
| author_facet | Miriam Martínez-Huélamo Jose Rodríguez-Morató Anna Boronat Rafael de la Torre |
| author_sort | Miriam Martínez-Huélamo |
| collection | DOAJ |
| description | Strong adherence to a Mediterranean diet is associated with improved cognitive function and a lower prevalence of mild cognitive impairment. Olive oil and red wine are rich sources of polyphenols which are responsible in part for the beneficial effects on cognitive functioning. Polyphenols induce endogenous antioxidant defense mechanisms by modulating transcription factors such as the nuclear factor (erythroid-derived 2)-like 2 (Nrf2). This review discusses the scientific data supporting the modulating effect of olive oil and red wine polyphenols on Nrf2 expression, and the potential health benefits associated with cognitive functioning. |
| first_indexed | 2024-03-12T04:39:38Z |
| format | Article |
| id | doaj.art-076ecb24c8044dba9fdc3e75c3d1a437 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T04:39:38Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-076ecb24c8044dba9fdc3e75c3d1a4372023-09-03T09:45:43ZengMDPI AGAntioxidants2076-39212017-09-01647310.3390/antiox6040073antiox6040073Modulation of Nrf2 by Olive Oil and Wine Polyphenols and NeuroprotectionMiriam Martínez-Huélamo0Jose Rodríguez-Morató1Anna Boronat2Rafael de la Torre3Integrated Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, Dr. Aiguader 88, 08003 Barcelona, SpainIntegrated Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, Dr. Aiguader 88, 08003 Barcelona, SpainIntegrated Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, Dr. Aiguader 88, 08003 Barcelona, SpainIntegrated Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, Dr. Aiguader 88, 08003 Barcelona, SpainStrong adherence to a Mediterranean diet is associated with improved cognitive function and a lower prevalence of mild cognitive impairment. Olive oil and red wine are rich sources of polyphenols which are responsible in part for the beneficial effects on cognitive functioning. Polyphenols induce endogenous antioxidant defense mechanisms by modulating transcription factors such as the nuclear factor (erythroid-derived 2)-like 2 (Nrf2). This review discusses the scientific data supporting the modulating effect of olive oil and red wine polyphenols on Nrf2 expression, and the potential health benefits associated with cognitive functioning.https://www.mdpi.com/2076-3921/6/4/73polyphenolsNrf2wineolive oilcognitive functionresveratrolhydroxytyrosol |
| spellingShingle | Miriam Martínez-Huélamo Jose Rodríguez-Morató Anna Boronat Rafael de la Torre Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection Antioxidants polyphenols Nrf2 wine olive oil cognitive function resveratrol hydroxytyrosol |
| title | Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection |
| title_full | Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection |
| title_fullStr | Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection |
| title_full_unstemmed | Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection |
| title_short | Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection |
| title_sort | modulation of nrf2 by olive oil and wine polyphenols and neuroprotection |
| topic | polyphenols Nrf2 wine olive oil cognitive function resveratrol hydroxytyrosol |
| url | https://www.mdpi.com/2076-3921/6/4/73 |
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