ISG15 Connects Autophagy and IFN-γ-Dependent Control of <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection in Human Cells

ISG15 Connects Autophagy and IFN-γ-Dependent Control of <named-content content-type="genus-species">Toxoplasma gondii</named-content> Infection in Human Cells

ABSTRACT The intracellular protozoan parasite Toxoplasma gondii is capable of infecting most nucleated cells, where it survives in a specially modified compartment called the parasitophorous vacuole (PV). Interferon gamma (IFN-γ) is the major cytokine involved in activating cell-autonomous immune re...

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Bibliographic Details
Main Authors: Jaya Bhushan, Joshua B. Radke, Yi-Chieh Perng, Michael Mcallaster, Deborah J. Lenschow, Herbert W. Virgin, L. David Sibley
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mBio
Subjects:
ATG5
BioID
ubiquitin
autophagy adaptors
LC3
ISGylation
Online Access:https://journals.asm.org/doi/10.1128/mBio.00852-20

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