Cancer stem cells and their niche in cancer progression and therapy
Abstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CS...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-023-03130-2 |
| _version_ | 1827602745206505472 |
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| author | Qiuping Liu Zongliang Guo Guoyin Li Yunxia Zhang Xiaomeng Liu Bing Li Jinping Wang Xiaoyan Li |
| author_facet | Qiuping Liu Zongliang Guo Guoyin Li Yunxia Zhang Xiaomeng Liu Bing Li Jinping Wang Xiaoyan Li |
| author_sort | Qiuping Liu |
| collection | DOAJ |
| description | Abstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer. |
| first_indexed | 2024-03-09T05:24:53Z |
| format | Article |
| id | doaj.art-076f8d6e9c0d47c2876336390d88daf9 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-03-09T05:24:53Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-076f8d6e9c0d47c2876336390d88daf92023-12-03T12:36:56ZengBMCCancer Cell International1475-28672023-12-0123111210.1186/s12935-023-03130-2Cancer stem cells and their niche in cancer progression and therapyQiuping Liu0Zongliang Guo1Guoyin Li2Yunxia Zhang3Xiaomeng Liu4Bing Li5Jinping Wang6Xiaoyan Li7Institute of Translational Medicine, College of Life Science and Agronomy, Zhoukou Normal UniversityDepartment of General Surgery, Shanxi Province Cancer Hospital, Affiliated of Shanxi Medical UniversityInstitute of Translational Medicine, College of Life Science and Agronomy, Zhoukou Normal UniversityInstitute of Translational Medicine, College of Life Science and Agronomy, Zhoukou Normal UniversityInstitute of Translational Medicine, College of Life Science and Agronomy, Zhoukou Normal UniversityInstitute of Translational Medicine, College of Life Science and Agronomy, Zhoukou Normal UniversityDepartment of Ultrasound, Shanxi Province People’s HospitalDepartment of blood transfusion, Shanxi Provincial People’s HospitalAbstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer.https://doi.org/10.1186/s12935-023-03130-2cancer stem cellsCSC nicheCellular componentsExtracellular matrixTherapeutic strategies |
| spellingShingle | Qiuping Liu Zongliang Guo Guoyin Li Yunxia Zhang Xiaomeng Liu Bing Li Jinping Wang Xiaoyan Li Cancer stem cells and their niche in cancer progression and therapy Cancer Cell International cancer stem cells CSC niche Cellular components Extracellular matrix Therapeutic strategies |
| title | Cancer stem cells and their niche in cancer progression and therapy |
| title_full | Cancer stem cells and their niche in cancer progression and therapy |
| title_fullStr | Cancer stem cells and their niche in cancer progression and therapy |
| title_full_unstemmed | Cancer stem cells and their niche in cancer progression and therapy |
| title_short | Cancer stem cells and their niche in cancer progression and therapy |
| title_sort | cancer stem cells and their niche in cancer progression and therapy |
| topic | cancer stem cells CSC niche Cellular components Extracellular matrix Therapeutic strategies |
| url | https://doi.org/10.1186/s12935-023-03130-2 |
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