An integrated safety analysis of intravenous ibuprofen (Caldolor®) in adults
Stephen R Southworth,1 Emily J Woodward,2 Alex Peng,2 Amy D Rock21North Mississippi Sports Medicine and Orthopaedic Clinic, PLLC, Tupelo, MS, 2Department of Research and Development, Cumberland Pharmaceuticals Inc., Nashville, TN, USAAbstract: Intravenous (IV) nonsteroidal anti-inflammatory drugs su...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015-10-01
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| Series: | Journal of Pain Research |
| Online Access: | https://www.dovepress.com/an-integrated-safety-analysis-of-intravenous-ibuprofen-caldolorreg-in--peer-reviewed-article-JPR |
| _version_ | 1818240881812045824 |
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| author | Southworth SR Woodward EJ Peng A Rock AD |
| author_facet | Southworth SR Woodward EJ Peng A Rock AD |
| author_sort | Southworth SR |
| collection | DOAJ |
| description | Stephen R Southworth,1 Emily J Woodward,2 Alex Peng,2 Amy D Rock21North Mississippi Sports Medicine and Orthopaedic Clinic, PLLC, Tupelo, MS, 2Department of Research and Development, Cumberland Pharmaceuticals Inc., Nashville, TN, USAAbstract: Intravenous (IV) nonsteroidal anti-inflammatory drugs such as IV ibuprofen are increasingly used as a component of multimodal pain management in the inpatient and outpatient settings. The safety of IV ibuprofen as assessed in ten sponsored clinical studies is presented in this analysis. Overall, 1,752 adult patients have been included in safety and efficacy trials over 11 years; 1,220 of these patients have received IV ibuprofen and 532 received either placebo or comparator medication. The incidence of adverse events (AEs), serious AEs, and changes in vital signs and clinically significant laboratory parameters have been summarized and compared to patients receiving placebo or active comparator drug. Overall, IV ibuprofen has been well tolerated by hospitalized and outpatient patients when administered both prior to surgery and postoperatively as well as for nonsurgical pain or fever. The overall incidence of AEs is lower in patients receiving IV ibuprofen as compared to those receiving placebo in this integrated analysis. Specific analysis of hematological and renal effects showed no increased risk for patients receiving IV ibuprofen. A subset analysis of elderly patients suggests that no dose adjustment is needed in this higher risk population. This integrated safety analysis demonstrates that IV ibuprofen can be safely administered prior to surgery and continued in the postoperative period as a component of multimodal pain management.Keywords: NSAID, surgical pain, fever, perioperative analgesia, critical care, multimodal pain management |
| first_indexed | 2024-12-12T13:20:30Z |
| format | Article |
| id | doaj.art-076fcfa7f28a4984a015a1275acb75ae |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-12-12T13:20:30Z |
| publishDate | 2015-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-076fcfa7f28a4984a015a1275acb75ae2022-12-22T00:23:19ZengDove Medical PressJournal of Pain Research1178-70902015-10-012015default75376524300An integrated safety analysis of intravenous ibuprofen (Caldolor®) in adultsSouthworth SRWoodward EJPeng ARock ADStephen R Southworth,1 Emily J Woodward,2 Alex Peng,2 Amy D Rock21North Mississippi Sports Medicine and Orthopaedic Clinic, PLLC, Tupelo, MS, 2Department of Research and Development, Cumberland Pharmaceuticals Inc., Nashville, TN, USAAbstract: Intravenous (IV) nonsteroidal anti-inflammatory drugs such as IV ibuprofen are increasingly used as a component of multimodal pain management in the inpatient and outpatient settings. The safety of IV ibuprofen as assessed in ten sponsored clinical studies is presented in this analysis. Overall, 1,752 adult patients have been included in safety and efficacy trials over 11 years; 1,220 of these patients have received IV ibuprofen and 532 received either placebo or comparator medication. The incidence of adverse events (AEs), serious AEs, and changes in vital signs and clinically significant laboratory parameters have been summarized and compared to patients receiving placebo or active comparator drug. Overall, IV ibuprofen has been well tolerated by hospitalized and outpatient patients when administered both prior to surgery and postoperatively as well as for nonsurgical pain or fever. The overall incidence of AEs is lower in patients receiving IV ibuprofen as compared to those receiving placebo in this integrated analysis. Specific analysis of hematological and renal effects showed no increased risk for patients receiving IV ibuprofen. A subset analysis of elderly patients suggests that no dose adjustment is needed in this higher risk population. This integrated safety analysis demonstrates that IV ibuprofen can be safely administered prior to surgery and continued in the postoperative period as a component of multimodal pain management.Keywords: NSAID, surgical pain, fever, perioperative analgesia, critical care, multimodal pain managementhttps://www.dovepress.com/an-integrated-safety-analysis-of-intravenous-ibuprofen-caldolorreg-in--peer-reviewed-article-JPR |
| spellingShingle | Southworth SR Woodward EJ Peng A Rock AD An integrated safety analysis of intravenous ibuprofen (Caldolor®) in adults Journal of Pain Research |
| title | An integrated safety analysis of intravenous ibuprofen (Caldolor®) in adults |
| title_full | An integrated safety analysis of intravenous ibuprofen (Caldolor®) in adults |
| title_fullStr | An integrated safety analysis of intravenous ibuprofen (Caldolor®) in adults |
| title_full_unstemmed | An integrated safety analysis of intravenous ibuprofen (Caldolor®) in adults |
| title_short | An integrated safety analysis of intravenous ibuprofen (Caldolor®) in adults |
| title_sort | integrated safety analysis of intravenous ibuprofen caldolor reg in adults |
| url | https://www.dovepress.com/an-integrated-safety-analysis-of-intravenous-ibuprofen-caldolorreg-in--peer-reviewed-article-JPR |
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