Cardiorespiratory and Neuroprotective Effects of Caffeine in Neonate Animal Models
Caffeine is widely used to improve neonatal health in animals with low vitality. Due to its pharmacokinetics and pharmacodynamics, caffeine stimulates the cardiorespiratory system by antagonism of adenosine receptors and alteration in Ca<sup>+2</sup> ion channel activity. Moreover, the a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/11/1769 |
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| author | Daniel Mota-Rojas Dina Villanueva-García Ismael Hernández-Ávalos Alejandro Casas-Alvarado Adriana Domínguez-Oliva Karina Lezama-García Agatha Miranda-Cortés Julio Martínez-Burnes |
| author_facet | Daniel Mota-Rojas Dina Villanueva-García Ismael Hernández-Ávalos Alejandro Casas-Alvarado Adriana Domínguez-Oliva Karina Lezama-García Agatha Miranda-Cortés Julio Martínez-Burnes |
| author_sort | Daniel Mota-Rojas |
| collection | DOAJ |
| description | Caffeine is widely used to improve neonatal health in animals with low vitality. Due to its pharmacokinetics and pharmacodynamics, caffeine stimulates the cardiorespiratory system by antagonism of adenosine receptors and alteration in Ca<sup>+2</sup> ion channel activity. Moreover, the availability of intracellular Ca<sup>+2</sup> also has positive inotropic effects by increasing heart contractibility and by having a possible positive effect on neonate vitality. Nonetheless, since neonatal enzymatic and tissular systems are immature at birth, there is a controversy about whether caffeine is an effective therapy for newborns. This review aims to analyze the basic concepts of caffeine in neonatal animal models (rat and mouse pups, goat kids, lambs, and piglets), and it will discuss the neuroprotective effect and its physiological actions in reducing apnea in newborns. |
| first_indexed | 2024-03-11T03:12:07Z |
| format | Article |
| id | doaj.art-07705c19d1ce4dea8dd6595f7be4c084 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-11T03:12:07Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-07705c19d1ce4dea8dd6595f7be4c0842023-11-18T07:29:28ZengMDPI AGAnimals2076-26152023-05-011311176910.3390/ani13111769Cardiorespiratory and Neuroprotective Effects of Caffeine in Neonate Animal ModelsDaniel Mota-Rojas0Dina Villanueva-García1Ismael Hernández-Ávalos2Alejandro Casas-Alvarado3Adriana Domínguez-Oliva4Karina Lezama-García5Agatha Miranda-Cortés6Julio Martínez-Burnes7Neurophysiology, Behavior and Animal Welfare Assessment, Universidad Autónoma Metropolitana (UAM), Mexico City 04960, MexicoDivision of Neonatology, National Institute of Health, Hospital Infantil de México Federico Gómez, Mexico City 06720, MexicoClinical Pharmacology and Veterinary Anesthesia, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México (UNAM), Cuautitlán 54714, MexicoNeurophysiology, Behavior and Animal Welfare Assessment, Universidad Autónoma Metropolitana (UAM), Mexico City 04960, MexicoNeurophysiology, Behavior and Animal Welfare Assessment, Universidad Autónoma Metropolitana (UAM), Mexico City 04960, MexicoNeurophysiology, Behavior and Animal Welfare Assessment, Universidad Autónoma Metropolitana (UAM), Mexico City 04960, MexicoClinical Pharmacology and Veterinary Anesthesia, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México (UNAM), Cuautitlán 54714, MexicoFacultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Tamaulipas, Victoria City 87000, MexicoCaffeine is widely used to improve neonatal health in animals with low vitality. Due to its pharmacokinetics and pharmacodynamics, caffeine stimulates the cardiorespiratory system by antagonism of adenosine receptors and alteration in Ca<sup>+2</sup> ion channel activity. Moreover, the availability of intracellular Ca<sup>+2</sup> also has positive inotropic effects by increasing heart contractibility and by having a possible positive effect on neonate vitality. Nonetheless, since neonatal enzymatic and tissular systems are immature at birth, there is a controversy about whether caffeine is an effective therapy for newborns. This review aims to analyze the basic concepts of caffeine in neonatal animal models (rat and mouse pups, goat kids, lambs, and piglets), and it will discuss the neuroprotective effect and its physiological actions in reducing apnea in newborns.https://www.mdpi.com/2076-2615/13/11/1769positive inotropic effecthypoxianewbornmethylxanthine |
| spellingShingle | Daniel Mota-Rojas Dina Villanueva-García Ismael Hernández-Ávalos Alejandro Casas-Alvarado Adriana Domínguez-Oliva Karina Lezama-García Agatha Miranda-Cortés Julio Martínez-Burnes Cardiorespiratory and Neuroprotective Effects of Caffeine in Neonate Animal Models Animals positive inotropic effect hypoxia newborn methylxanthine |
| title | Cardiorespiratory and Neuroprotective Effects of Caffeine in Neonate Animal Models |
| title_full | Cardiorespiratory and Neuroprotective Effects of Caffeine in Neonate Animal Models |
| title_fullStr | Cardiorespiratory and Neuroprotective Effects of Caffeine in Neonate Animal Models |
| title_full_unstemmed | Cardiorespiratory and Neuroprotective Effects of Caffeine in Neonate Animal Models |
| title_short | Cardiorespiratory and Neuroprotective Effects of Caffeine in Neonate Animal Models |
| title_sort | cardiorespiratory and neuroprotective effects of caffeine in neonate animal models |
| topic | positive inotropic effect hypoxia newborn methylxanthine |
| url | https://www.mdpi.com/2076-2615/13/11/1769 |
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