Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country.

A shift in dengue cases toward the adult population, accompanied by an increased risk of severe cases of dengue in the elderly, has created an important emerging issue in the past decade. To understand the level of past DENV infection among older adults after a large dengue outbreak occurred in sout...

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Main Authors: Yi-Hua Pan, Mei-Ying Liao, Yu-Wen Chien, Tzong-Shiann Ho, Hui-Ying Ko, Chin-Rur Yang, Shu-Fen Chang, Chia-Yi Yu, Shu-Yu Lin, Pin-Wei Shih, Pei-Yun Shu, Day-Yu Chao, Chao-Ying Pan, Hong-Ming Chen, Guey-Chuen Perng, Chia-Chi Ku, Chwan-Chuen King
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0009312
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author Yi-Hua Pan
Mei-Ying Liao
Yu-Wen Chien
Tzong-Shiann Ho
Hui-Ying Ko
Chin-Rur Yang
Shu-Fen Chang
Chia-Yi Yu
Shu-Yu Lin
Pin-Wei Shih
Pei-Yun Shu
Day-Yu Chao
Chao-Ying Pan
Hong-Ming Chen
Guey-Chuen Perng
Chia-Chi Ku
Chwan-Chuen King
author_facet Yi-Hua Pan
Mei-Ying Liao
Yu-Wen Chien
Tzong-Shiann Ho
Hui-Ying Ko
Chin-Rur Yang
Shu-Fen Chang
Chia-Yi Yu
Shu-Yu Lin
Pin-Wei Shih
Pei-Yun Shu
Day-Yu Chao
Chao-Ying Pan
Hong-Ming Chen
Guey-Chuen Perng
Chia-Chi Ku
Chwan-Chuen King
author_sort Yi-Hua Pan
collection DOAJ
description A shift in dengue cases toward the adult population, accompanied by an increased risk of severe cases of dengue in the elderly, has created an important emerging issue in the past decade. To understand the level of past DENV infection among older adults after a large dengue outbreak occurred in southern Taiwan in 2015, we screened 1498 and 2603 serum samples from healthy residents aged ≥ 40 years in Kaohsiung City and Tainan City, respectively, to assess the seroprevalence of anti-DENV IgG in 2016. Seropositive samples were verified to exclude cross-reaction from Japanese encephalitis virus (JEV), using DENV/JEV-NS1 indirect IgG ELISA. We further identified viral serotypes and secondary DENV infections among positive samples in the two cities. The overall age-standardized seroprevalence of DENV-IgG among participants was 25.77% in Kaohsiung and 11.40% in Tainan, and the seroprevalence was significantly higher in older age groups of both cities. Although the percentages of secondary DENV infection in Kaohsiung and Tainan were very similar (43.09% and 44.76%, respectively), DENV-1 and DENV-2 spanned a wider age range in Kaohsiung, whereas DENV-2 was dominant in Tainan. As very few studies have obtained the serostatus of DENV infection in older adults and the elderly, this study highlights the need for further investigation into antibody status, as well as the safety and efficacy of dengue vaccination in these older populations.
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spelling doaj.art-077403a6327342e0880a444c75ad5fd52022-12-21T23:11:00ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352021-04-01154e000931210.1371/journal.pntd.0009312Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country.Yi-Hua PanMei-Ying LiaoYu-Wen ChienTzong-Shiann HoHui-Ying KoChin-Rur YangShu-Fen ChangChia-Yi YuShu-Yu LinPin-Wei ShihPei-Yun ShuDay-Yu ChaoChao-Ying PanHong-Ming ChenGuey-Chuen PerngChia-Chi KuChwan-Chuen KingA shift in dengue cases toward the adult population, accompanied by an increased risk of severe cases of dengue in the elderly, has created an important emerging issue in the past decade. To understand the level of past DENV infection among older adults after a large dengue outbreak occurred in southern Taiwan in 2015, we screened 1498 and 2603 serum samples from healthy residents aged ≥ 40 years in Kaohsiung City and Tainan City, respectively, to assess the seroprevalence of anti-DENV IgG in 2016. Seropositive samples were verified to exclude cross-reaction from Japanese encephalitis virus (JEV), using DENV/JEV-NS1 indirect IgG ELISA. We further identified viral serotypes and secondary DENV infections among positive samples in the two cities. The overall age-standardized seroprevalence of DENV-IgG among participants was 25.77% in Kaohsiung and 11.40% in Tainan, and the seroprevalence was significantly higher in older age groups of both cities. Although the percentages of secondary DENV infection in Kaohsiung and Tainan were very similar (43.09% and 44.76%, respectively), DENV-1 and DENV-2 spanned a wider age range in Kaohsiung, whereas DENV-2 was dominant in Tainan. As very few studies have obtained the serostatus of DENV infection in older adults and the elderly, this study highlights the need for further investigation into antibody status, as well as the safety and efficacy of dengue vaccination in these older populations.https://doi.org/10.1371/journal.pntd.0009312
spellingShingle Yi-Hua Pan
Mei-Ying Liao
Yu-Wen Chien
Tzong-Shiann Ho
Hui-Ying Ko
Chin-Rur Yang
Shu-Fen Chang
Chia-Yi Yu
Shu-Yu Lin
Pin-Wei Shih
Pei-Yun Shu
Day-Yu Chao
Chao-Ying Pan
Hong-Ming Chen
Guey-Chuen Perng
Chia-Chi Ku
Chwan-Chuen King
Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country.
PLoS Neglected Tropical Diseases
title Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country.
title_full Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country.
title_fullStr Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country.
title_full_unstemmed Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country.
title_short Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country.
title_sort use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non endemic country
url https://doi.org/10.1371/journal.pntd.0009312
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