Network regression analysis in transcriptome-wide association studies

Network regression analysis in transcriptome-wide association studies

Abstract Background Transcriptome-wide association studies (TWASs) have shown great promise in interpreting the findings from genome-wide association studies (GWASs) and exploring the disease mechanisms, by integrating GWAS and eQTL mapping studies. Almost all TWAS methods only focus on one gene at...

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Bibliographic Details
Main Authors: Xiuyuan Jin, Liye Zhang, Jiadong Ji, Tao Ju, Jinghua Zhao, Zhongshang Yuan
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Genomics
Subjects:
TWAS
Biological networks
Dirichlet process regression
Pointwise mutual information
Blood pressure
Online Access:https://doi.org/10.1186/s12864-022-08809-w

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