Immunopathogenesis in Trypanosoma cruzi infection: a role for suppressed macrophages and apoptotic cells

Immunopathogenesis in Trypanosoma cruzi infection: a role for suppressed macrophages and apoptotic cells

During Trypanosoma cruzi infection, macrophages phagocytose parasites and remove apoptotic cells through efferocytosis. While macrophage 1 (M1) produces proinflammatory cytokines and NO and fights infection, M2 macrophages are permissive host cells that express arginase 1 and play a role in tissue r...

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Bibliographic Details
Main Authors: Natália S. Vellozo, Thayane C. Matos-Silva, Marcela F. Lopes
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
apoptosis
Chagas disease
efferocytosis
fibrosis
heart pathology
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1244071/full

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