Disease Burden, Risk Factors, and Trends of Leukaemia: A Global Analysis
Leukaemia accounted for approximately 2.5% of all new cancer incidence and 3.1% of cancer-related mortality. The investigation of its risk factors and epidemiologic trends could help describe the geographical distribution and identify high-risk population groups. This study aimed to evaluate the glo...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.904292/full |
| _version_ | 1818511797301280768 |
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| author | Junjie Huang Sze Chai Chan Chun Ho Ngai Veeleah Lok Lin Zhang Lin Zhang Don Eliseo Lucero-Prisno Wanghong Xu Zhi-Jie Zheng Edmar Elcarte Mellissa Withers Martin C. S. Wong Martin C. S. Wong Martin C. S. Wong |
| author_facet | Junjie Huang Sze Chai Chan Chun Ho Ngai Veeleah Lok Lin Zhang Lin Zhang Don Eliseo Lucero-Prisno Wanghong Xu Zhi-Jie Zheng Edmar Elcarte Mellissa Withers Martin C. S. Wong Martin C. S. Wong Martin C. S. Wong |
| author_sort | Junjie Huang |
| collection | DOAJ |
| description | Leukaemia accounted for approximately 2.5% of all new cancer incidence and 3.1% of cancer-related mortality. The investigation of its risk factors and epidemiologic trends could help describe the geographical distribution and identify high-risk population groups. This study aimed to evaluate the global incidence, mortality, associated risk factors, and temporal trends of leukaemia by sex, age, and country. We extracted incidence and mortality of leukaemia from GLOBOCAN, CI5, WHO mortality database, NORDCAN, and SEER. We searched the WHO Global Health Observatory data repository for the age-standardised prevalence of lifestyle and metabolic risk factors. We tested the trends by calculating Average Annual Percentage Change (AAPC) from Joinpoint regression. The age-standardized rate of incidence and mortality were 5.4 and 3.3 per 100,000 globally. The incidence and mortality of leukaemia were associated with Human Development Index, Gross Domestics Products per capita, prevalence of smoking, physical activity, overweight, obesity, and hypercholesterolaemia at the country level. Overall, more countries were showing decreasing trends than increasing trends in incidence and mortality. However, an increasing trend of leukaemia incidence was found in Germany, Korea, Japan, Canada and the United Kingdom (AAPC, 2.32-0.98) while its mortality increased in the Philippines, Ecuador, Belarus, and Thailand (AAPC, 2.49-1.23). There was a decreasing trend of leukaemia for the past decade while an increase in incidence and mortality was observed in some populations. More intensive lifestyle modifications should be implemented to control the increasing trends of leukaemia in regions with these trends. Future studies may explore the reasons behind these epidemiological transitions. |
| first_indexed | 2024-12-10T23:37:57Z |
| format | Article |
| id | doaj.art-077993bbe4414f008213f3c46ab3bc3d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T23:37:57Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-077993bbe4414f008213f3c46ab3bc3d2022-12-22T01:29:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.904292904292Disease Burden, Risk Factors, and Trends of Leukaemia: A Global AnalysisJunjie Huang0Sze Chai Chan1Chun Ho Ngai2Veeleah Lok3Lin Zhang4Lin Zhang5Don Eliseo Lucero-Prisno6Wanghong Xu7Zhi-Jie Zheng8Edmar Elcarte9Mellissa Withers10Martin C. S. Wong11Martin C. S. Wong12Martin C. S. Wong13The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaDepartment of Global Public Health, Karolinska Institute, Karolinska University Hospital, Stockholm, SwedenSchool of Population and Global Health, The University of Melbourne, Carlton, VIC, AustraliaSchool of Public Health, The Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United KingdomSchool of Public Health, Fudan University, Shanghai, ChinaDepartment of Global Health, School of Public Health, Peking University, Beijing, ChinaCollege of Nursing, University of the Philippines, Manila, PhilippinesDepartment of Preventive Medicine, Institute for Global Health, University of Southern California, Los Angeles, CA, United StatesThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaSchool of Public Health, The Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Global Health, School of Public Health, Peking University, Beijing, ChinaLeukaemia accounted for approximately 2.5% of all new cancer incidence and 3.1% of cancer-related mortality. The investigation of its risk factors and epidemiologic trends could help describe the geographical distribution and identify high-risk population groups. This study aimed to evaluate the global incidence, mortality, associated risk factors, and temporal trends of leukaemia by sex, age, and country. We extracted incidence and mortality of leukaemia from GLOBOCAN, CI5, WHO mortality database, NORDCAN, and SEER. We searched the WHO Global Health Observatory data repository for the age-standardised prevalence of lifestyle and metabolic risk factors. We tested the trends by calculating Average Annual Percentage Change (AAPC) from Joinpoint regression. The age-standardized rate of incidence and mortality were 5.4 and 3.3 per 100,000 globally. The incidence and mortality of leukaemia were associated with Human Development Index, Gross Domestics Products per capita, prevalence of smoking, physical activity, overweight, obesity, and hypercholesterolaemia at the country level. Overall, more countries were showing decreasing trends than increasing trends in incidence and mortality. However, an increasing trend of leukaemia incidence was found in Germany, Korea, Japan, Canada and the United Kingdom (AAPC, 2.32-0.98) while its mortality increased in the Philippines, Ecuador, Belarus, and Thailand (AAPC, 2.49-1.23). There was a decreasing trend of leukaemia for the past decade while an increase in incidence and mortality was observed in some populations. More intensive lifestyle modifications should be implemented to control the increasing trends of leukaemia in regions with these trends. Future studies may explore the reasons behind these epidemiological transitions.https://www.frontiersin.org/articles/10.3389/fonc.2022.904292/fullLeukaemiaincidencemortalityrisk factorstemporal trend |
| spellingShingle | Junjie Huang Sze Chai Chan Chun Ho Ngai Veeleah Lok Lin Zhang Lin Zhang Don Eliseo Lucero-Prisno Wanghong Xu Zhi-Jie Zheng Edmar Elcarte Mellissa Withers Martin C. S. Wong Martin C. S. Wong Martin C. S. Wong Disease Burden, Risk Factors, and Trends of Leukaemia: A Global Analysis Frontiers in Oncology Leukaemia incidence mortality risk factors temporal trend |
| title | Disease Burden, Risk Factors, and Trends of Leukaemia: A Global Analysis |
| title_full | Disease Burden, Risk Factors, and Trends of Leukaemia: A Global Analysis |
| title_fullStr | Disease Burden, Risk Factors, and Trends of Leukaemia: A Global Analysis |
| title_full_unstemmed | Disease Burden, Risk Factors, and Trends of Leukaemia: A Global Analysis |
| title_short | Disease Burden, Risk Factors, and Trends of Leukaemia: A Global Analysis |
| title_sort | disease burden risk factors and trends of leukaemia a global analysis |
| topic | Leukaemia incidence mortality risk factors temporal trend |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.904292/full |
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