High-resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography.
OBJECTIVE: To generate high-resolution maps of the viscoelastic properties of human brain parenchyma for presurgical quantitative assessment in glioblastoma (GB). METHODS: Twenty-two GB patients underwent routine presurgical work-up supplemented by additional multifrequency magnetic resonance elasto...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4206430?pdf=render |
| _version_ | 1819263980826263552 |
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| author | Kaspar-Josche Streitberger Martin Reiss-Zimmermann Florian Baptist Freimann Simon Bayerl Jing Guo Felix Arlt Jens Wuerfel Jürgen Braun Karl-Titus Hoffmann Ingolf Sack |
| author_facet | Kaspar-Josche Streitberger Martin Reiss-Zimmermann Florian Baptist Freimann Simon Bayerl Jing Guo Felix Arlt Jens Wuerfel Jürgen Braun Karl-Titus Hoffmann Ingolf Sack |
| author_sort | Kaspar-Josche Streitberger |
| collection | DOAJ |
| description | OBJECTIVE: To generate high-resolution maps of the viscoelastic properties of human brain parenchyma for presurgical quantitative assessment in glioblastoma (GB). METHODS: Twenty-two GB patients underwent routine presurgical work-up supplemented by additional multifrequency magnetic resonance elastography. Two three-dimensional viscoelastic parameter maps, magnitude |G*|, and phase angle φ of the complex shear modulus were reconstructed by inversion of full wave field data in 2-mm isotropic resolution at seven harmonic drive frequencies ranging from 30 to 60 Hz. RESULTS: Mechanical brain maps confirmed that GB are composed of stiff and soft compartments, resulting in high intratumor heterogeneity. GB could be easily differentiated from healthy reference tissue by their reduced viscous behavior quantified by φ (0.37±0.08 vs. 0.58±0.07). |G*|, which in solids more relates to the material's stiffness, was significantly reduced in GB with a mean value of 1.32±0.26 kPa compared to 1.54±0.27 kPa in healthy tissue (P = 0.001). However, some GB (5 of 22) showed increased stiffness. CONCLUSION: GB are generally less viscous and softer than healthy brain parenchyma. Unrelated to the morphology-based contrast of standard magnetic resonance imaging, elastography provides an entirely new neuroradiological marker and contrast related to the biomechanical properties of tumors. |
| first_indexed | 2024-12-23T20:22:13Z |
| format | Article |
| id | doaj.art-077a56a69ae443188479817953e9dc16 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T20:22:13Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-077a56a69ae443188479817953e9dc162022-12-21T17:32:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e11058810.1371/journal.pone.0110588High-resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography.Kaspar-Josche StreitbergerMartin Reiss-ZimmermannFlorian Baptist FreimannSimon BayerlJing GuoFelix ArltJens WuerfelJürgen BraunKarl-Titus HoffmannIngolf SackOBJECTIVE: To generate high-resolution maps of the viscoelastic properties of human brain parenchyma for presurgical quantitative assessment in glioblastoma (GB). METHODS: Twenty-two GB patients underwent routine presurgical work-up supplemented by additional multifrequency magnetic resonance elastography. Two three-dimensional viscoelastic parameter maps, magnitude |G*|, and phase angle φ of the complex shear modulus were reconstructed by inversion of full wave field data in 2-mm isotropic resolution at seven harmonic drive frequencies ranging from 30 to 60 Hz. RESULTS: Mechanical brain maps confirmed that GB are composed of stiff and soft compartments, resulting in high intratumor heterogeneity. GB could be easily differentiated from healthy reference tissue by their reduced viscous behavior quantified by φ (0.37±0.08 vs. 0.58±0.07). |G*|, which in solids more relates to the material's stiffness, was significantly reduced in GB with a mean value of 1.32±0.26 kPa compared to 1.54±0.27 kPa in healthy tissue (P = 0.001). However, some GB (5 of 22) showed increased stiffness. CONCLUSION: GB are generally less viscous and softer than healthy brain parenchyma. Unrelated to the morphology-based contrast of standard magnetic resonance imaging, elastography provides an entirely new neuroradiological marker and contrast related to the biomechanical properties of tumors.http://europepmc.org/articles/PMC4206430?pdf=render |
| spellingShingle | Kaspar-Josche Streitberger Martin Reiss-Zimmermann Florian Baptist Freimann Simon Bayerl Jing Guo Felix Arlt Jens Wuerfel Jürgen Braun Karl-Titus Hoffmann Ingolf Sack High-resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography. PLoS ONE |
| title | High-resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography. |
| title_full | High-resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography. |
| title_fullStr | High-resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography. |
| title_full_unstemmed | High-resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography. |
| title_short | High-resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography. |
| title_sort | high resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography |
| url | http://europepmc.org/articles/PMC4206430?pdf=render |
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