Neurological Complications of Conventional and Novel Anticancer Treatments
Various neurological complications, affecting both the central and peripheral nervous system, can frequently be experienced by cancer survivors after exposure to conventional chemotherapy, but also to modern immunotherapy. In this review, we provide an overview of the most well-known adverse events...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/24/6088 |
| _version_ | 1797461055175131136 |
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| author | Paola Alberti Alessandro Salvalaggio Andreas A. Argyriou Jordi Bruna Andrea Visentin Guido Cavaletti Chiara Briani |
| author_facet | Paola Alberti Alessandro Salvalaggio Andreas A. Argyriou Jordi Bruna Andrea Visentin Guido Cavaletti Chiara Briani |
| author_sort | Paola Alberti |
| collection | DOAJ |
| description | Various neurological complications, affecting both the central and peripheral nervous system, can frequently be experienced by cancer survivors after exposure to conventional chemotherapy, but also to modern immunotherapy. In this review, we provide an overview of the most well-known adverse events related to chemotherapy, with a focus on chemotherapy induced peripheral neurotoxicity, but we also address some emerging novel clinical entities related to cancer treatment, including chemotherapy-related cognitive impairment and immune-mediated adverse events. Unfortunately, efficacious curative or preventive treatment for all these neurological complications is still lacking. We provide a description of the possible mechanisms involved to drive future drug discovery in this field, both for symptomatic treatment and neuroprotection. |
| first_indexed | 2024-03-09T17:13:58Z |
| format | Article |
| id | doaj.art-077abcf4c8984a3d9a4ce1e157427f34 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:13:58Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-077abcf4c8984a3d9a4ce1e157427f342023-11-24T13:45:59ZengMDPI AGCancers2072-66942022-12-011424608810.3390/cancers14246088Neurological Complications of Conventional and Novel Anticancer TreatmentsPaola Alberti0Alessandro Salvalaggio1Andreas A. Argyriou2Jordi Bruna3Andrea Visentin4Guido Cavaletti5Chiara Briani6School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, ItalyNeurology Unit, Department of Neurosciences, University of Padova, 35131 Padova, ItalyNeurology Department, Agios Andreas State General Hospital of Patras, 26335 Patras, GreeceNeuro-Oncology Unit, Hospital Universitari de Bellvitge-ICO Hospitalet, Bellvitge Institute for Biomedical Research (IDIBELL), 08908 Barcelona, SpainHematology and Clinical Immunology Unit, Department of Medicine, University of Padova, 35131 Padova, ItalySchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, ItalyNeurology Unit, Department of Neurosciences, University of Padova, 35131 Padova, ItalyVarious neurological complications, affecting both the central and peripheral nervous system, can frequently be experienced by cancer survivors after exposure to conventional chemotherapy, but also to modern immunotherapy. In this review, we provide an overview of the most well-known adverse events related to chemotherapy, with a focus on chemotherapy induced peripheral neurotoxicity, but we also address some emerging novel clinical entities related to cancer treatment, including chemotherapy-related cognitive impairment and immune-mediated adverse events. Unfortunately, efficacious curative or preventive treatment for all these neurological complications is still lacking. We provide a description of the possible mechanisms involved to drive future drug discovery in this field, both for symptomatic treatment and neuroprotection.https://www.mdpi.com/2072-6694/14/24/6088chemotherapy-induced peripheral neurotoxicitychemotherapy-induced peripheral neuropathychemotherapy-related cognitive impairmentchemofogchemobrainimmune-checkpoint inhibitors neurotoxicity |
| spellingShingle | Paola Alberti Alessandro Salvalaggio Andreas A. Argyriou Jordi Bruna Andrea Visentin Guido Cavaletti Chiara Briani Neurological Complications of Conventional and Novel Anticancer Treatments Cancers chemotherapy-induced peripheral neurotoxicity chemotherapy-induced peripheral neuropathy chemotherapy-related cognitive impairment chemofog chemobrain immune-checkpoint inhibitors neurotoxicity |
| title | Neurological Complications of Conventional and Novel Anticancer Treatments |
| title_full | Neurological Complications of Conventional and Novel Anticancer Treatments |
| title_fullStr | Neurological Complications of Conventional and Novel Anticancer Treatments |
| title_full_unstemmed | Neurological Complications of Conventional and Novel Anticancer Treatments |
| title_short | Neurological Complications of Conventional and Novel Anticancer Treatments |
| title_sort | neurological complications of conventional and novel anticancer treatments |
| topic | chemotherapy-induced peripheral neurotoxicity chemotherapy-induced peripheral neuropathy chemotherapy-related cognitive impairment chemofog chemobrain immune-checkpoint inhibitors neurotoxicity |
| url | https://www.mdpi.com/2072-6694/14/24/6088 |
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