The chemical composition and toxic effects of aqueous extracts of Cyclocarya paliurus leaves
Cyclocarya paliurus leaves, which possess various bioactivities, have been widely used in dietary supplements or as ingredients in functional foods. However, limited information is available about the toxicity or safety concerns. In the present work, the maximum tolerated dose (MTD) and potential to...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.994055/full |
| _version_ | 1811257967057567744 |
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| author | Cencen Liu Cencen Liu Mouming Zhao Lingrong Wen Hongwei Zhao |
| author_facet | Cencen Liu Cencen Liu Mouming Zhao Lingrong Wen Hongwei Zhao |
| author_sort | Cencen Liu |
| collection | DOAJ |
| description | Cyclocarya paliurus leaves, which possess various bioactivities, have been widely used in dietary supplements or as ingredients in functional foods. However, limited information is available about the toxicity or safety concerns. In the present work, the maximum tolerated dose (MTD) and potential toxicity of the aqueous extracts of C. paliurus leaves (AECPL) were evaluated. Our results indicated that AECPL was rich in phenolics, flavonoids, and polysaccharides, which might be responsible for the health benefits of C. paliurus leaves. The MTD of AECPL was considered to be > 10,000 mg/kg BW in both male and female rats. The acute toxicity study was carried out by a 14-day repeat dose oral toxicity study. The results showed that the rats were all well-tolerated. No treatment-related mortality, abnormal clinical signs, body weight, or food consumption changes were reported during the study. Moreover, AECPL showed no adverse changes in the hematology, serum chemistry, urinalysis parameters, organ weights, gross finding, and histopathology. In this study, the non-observed-adverse-effect level of AECPL was 5,000 mg/kg BW/day, indicating AECPL was safe and can be used in the food industry. |
| first_indexed | 2024-04-12T18:05:51Z |
| format | Article |
| id | doaj.art-077c2d695ff04def8bfb9da984ed05c5 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T18:05:51Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-077c2d695ff04def8bfb9da984ed05c52022-12-22T03:21:59ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-09-01910.3389/fnut.2022.994055994055The chemical composition and toxic effects of aqueous extracts of Cyclocarya paliurus leavesCencen Liu0Cencen Liu1Mouming Zhao2Lingrong Wen3Hongwei Zhao4School of Food Science and Engineering, South China University of Technology, Guangzhou, ChinaInfinitus (China) Company Ltd., Guangzhou, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou, ChinaSouth China Botanical Garden, Chinese Academy of Sciences, Guangzhou, ChinaInfinitus (China) Company Ltd., Guangzhou, ChinaCyclocarya paliurus leaves, which possess various bioactivities, have been widely used in dietary supplements or as ingredients in functional foods. However, limited information is available about the toxicity or safety concerns. In the present work, the maximum tolerated dose (MTD) and potential toxicity of the aqueous extracts of C. paliurus leaves (AECPL) were evaluated. Our results indicated that AECPL was rich in phenolics, flavonoids, and polysaccharides, which might be responsible for the health benefits of C. paliurus leaves. The MTD of AECPL was considered to be > 10,000 mg/kg BW in both male and female rats. The acute toxicity study was carried out by a 14-day repeat dose oral toxicity study. The results showed that the rats were all well-tolerated. No treatment-related mortality, abnormal clinical signs, body weight, or food consumption changes were reported during the study. Moreover, AECPL showed no adverse changes in the hematology, serum chemistry, urinalysis parameters, organ weights, gross finding, and histopathology. In this study, the non-observed-adverse-effect level of AECPL was 5,000 mg/kg BW/day, indicating AECPL was safe and can be used in the food industry.https://www.frontiersin.org/articles/10.3389/fnut.2022.994055/fullsafetyCyclocarya paliurus leavesMTDchemical compositiontoxicity |
| spellingShingle | Cencen Liu Cencen Liu Mouming Zhao Lingrong Wen Hongwei Zhao The chemical composition and toxic effects of aqueous extracts of Cyclocarya paliurus leaves Frontiers in Nutrition safety Cyclocarya paliurus leaves MTD chemical composition toxicity |
| title | The chemical composition and toxic effects of aqueous extracts of Cyclocarya paliurus leaves |
| title_full | The chemical composition and toxic effects of aqueous extracts of Cyclocarya paliurus leaves |
| title_fullStr | The chemical composition and toxic effects of aqueous extracts of Cyclocarya paliurus leaves |
| title_full_unstemmed | The chemical composition and toxic effects of aqueous extracts of Cyclocarya paliurus leaves |
| title_short | The chemical composition and toxic effects of aqueous extracts of Cyclocarya paliurus leaves |
| title_sort | chemical composition and toxic effects of aqueous extracts of cyclocarya paliurus leaves |
| topic | safety Cyclocarya paliurus leaves MTD chemical composition toxicity |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.994055/full |
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