Micromolar Levofloxacin Sensor by Incorporating Highly Crystalline Co<sub>3</sub>O<sub>4</sub> into a Carbon Paste Electrode Structure
In this work, we successfully prepared a modified cobalt oxide (Co<sub>3</sub>O<sub>4</sub>) carbon paste electrode to detect Levofloxacin (LEV). By synthesizing Co<sub>3</sub>O<sub>4</sub> nanoparticles through the chemical coprecipitation method, the...
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MDPI AG
2024-01-01
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| Series: | Electrochem |
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| Online Access: | https://www.mdpi.com/2673-3293/5/1/3 |
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| author | Tijana Mutić Dalibor Stanković Dragan Manojlović Djordje Petrić Ferenc Pastor Vyacheslav V. Avdin Miloš Ognjanović Vesna Stanković |
| author_facet | Tijana Mutić Dalibor Stanković Dragan Manojlović Djordje Petrić Ferenc Pastor Vyacheslav V. Avdin Miloš Ognjanović Vesna Stanković |
| author_sort | Tijana Mutić |
| collection | DOAJ |
| description | In this work, we successfully prepared a modified cobalt oxide (Co<sub>3</sub>O<sub>4</sub>) carbon paste electrode to detect Levofloxacin (LEV). By synthesizing Co<sub>3</sub>O<sub>4</sub> nanoparticles through the chemical coprecipitation method, the electrochemical properties of the electrode and LEV were thoroughly investigated using CV, SWV, and EIS, while material properties were scrutinized using ICP-OES, TEM, SEM, and XRD. The results showed that the prepared electrode displayed a better electrocatalytic response than the bare carbon paste electrode. After optimizing SWV, the electrode exhibited a wide linear working range from 1 to 85 μM at pH 5 of BRBS as the supporting electrolyte. The selectivity of the proposed method was satisfactory, with good repeatability and reproducibility, strongly suggesting a potential application for determining LEV in real samples, particularly in pharmaceutical formulations. The practicality of the approach was demonstrated through good recoveries, and the morphology of the materials was found to be closely related to other parameters, indicating that the developed method can provide a cost-effective, rapid, selective, and sensitive means for LEV monitoring. Overall, this project has made significant progress towards developing a reliable method for detecting LEV and has opened up new opportunities for future research in this field. |
| first_indexed | 2024-04-24T18:21:58Z |
| format | Article |
| id | doaj.art-077cc26c5c4949759a4864398b6a34d9 |
| institution | Directory Open Access Journal |
| issn | 2673-3293 |
| language | English |
| last_indexed | 2024-04-24T18:21:58Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Electrochem |
| spelling | doaj.art-077cc26c5c4949759a4864398b6a34d92024-03-27T13:34:41ZengMDPI AGElectrochem2673-32932024-01-0151455610.3390/electrochem5010003Micromolar Levofloxacin Sensor by Incorporating Highly Crystalline Co<sub>3</sub>O<sub>4</sub> into a Carbon Paste Electrode StructureTijana Mutić0Dalibor Stanković1Dragan Manojlović2Djordje Petrić3Ferenc Pastor4Vyacheslav V. Avdin5Miloš Ognjanović6Vesna Stanković7Scientific Institution, Institute of Chemistry, Technology and Metallurgy, National Institute University of Belgrade, 11000 Belgrade, SerbiaFaculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, SerbiaFaculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, SerbiaFaculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, SerbiaFaculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, SerbiaDepartment for Ecology and Chemical Technology, South Ural State University, Lenin Prospect 76, 454080 Chelyabinsk, RussiaVINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovića Alasa 12-14, 11000 Belgrade, SerbiaScientific Institution, Institute of Chemistry, Technology and Metallurgy, National Institute University of Belgrade, 11000 Belgrade, SerbiaIn this work, we successfully prepared a modified cobalt oxide (Co<sub>3</sub>O<sub>4</sub>) carbon paste electrode to detect Levofloxacin (LEV). By synthesizing Co<sub>3</sub>O<sub>4</sub> nanoparticles through the chemical coprecipitation method, the electrochemical properties of the electrode and LEV were thoroughly investigated using CV, SWV, and EIS, while material properties were scrutinized using ICP-OES, TEM, SEM, and XRD. The results showed that the prepared electrode displayed a better electrocatalytic response than the bare carbon paste electrode. After optimizing SWV, the electrode exhibited a wide linear working range from 1 to 85 μM at pH 5 of BRBS as the supporting electrolyte. The selectivity of the proposed method was satisfactory, with good repeatability and reproducibility, strongly suggesting a potential application for determining LEV in real samples, particularly in pharmaceutical formulations. The practicality of the approach was demonstrated through good recoveries, and the morphology of the materials was found to be closely related to other parameters, indicating that the developed method can provide a cost-effective, rapid, selective, and sensitive means for LEV monitoring. Overall, this project has made significant progress towards developing a reliable method for detecting LEV and has opened up new opportunities for future research in this field.https://www.mdpi.com/2673-3293/5/1/3electrochemical sensorcarbon paste electrodeantibiotics |
| spellingShingle | Tijana Mutić Dalibor Stanković Dragan Manojlović Djordje Petrić Ferenc Pastor Vyacheslav V. Avdin Miloš Ognjanović Vesna Stanković Micromolar Levofloxacin Sensor by Incorporating Highly Crystalline Co<sub>3</sub>O<sub>4</sub> into a Carbon Paste Electrode Structure Electrochem electrochemical sensor carbon paste electrode antibiotics |
| title | Micromolar Levofloxacin Sensor by Incorporating Highly Crystalline Co<sub>3</sub>O<sub>4</sub> into a Carbon Paste Electrode Structure |
| title_full | Micromolar Levofloxacin Sensor by Incorporating Highly Crystalline Co<sub>3</sub>O<sub>4</sub> into a Carbon Paste Electrode Structure |
| title_fullStr | Micromolar Levofloxacin Sensor by Incorporating Highly Crystalline Co<sub>3</sub>O<sub>4</sub> into a Carbon Paste Electrode Structure |
| title_full_unstemmed | Micromolar Levofloxacin Sensor by Incorporating Highly Crystalline Co<sub>3</sub>O<sub>4</sub> into a Carbon Paste Electrode Structure |
| title_short | Micromolar Levofloxacin Sensor by Incorporating Highly Crystalline Co<sub>3</sub>O<sub>4</sub> into a Carbon Paste Electrode Structure |
| title_sort | micromolar levofloxacin sensor by incorporating highly crystalline co sub 3 sub o sub 4 sub into a carbon paste electrode structure |
| topic | electrochemical sensor carbon paste electrode antibiotics |
| url | https://www.mdpi.com/2673-3293/5/1/3 |
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